Andrew Beenken

TL;DR: The crystal structures of FGF19 alone and FGF23 in complex with sucrose octasulfate, a disaccharide chemically related to heparin, are presented, showing that Klotho/βKlotho have evolved as a compensatory mechanism for the poor ability ofHeparin/heparan sulfate to promote binding of F GF19, -21, and -23 to their cognate receptors.

TL;DR: FGF8 is identified as a gene implicated in GnRH deficiency in both humans and mice and demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling.

TL;DR: It is hypothesized that mutations in genes encoding a broader range of modulators of the FGFR1 pathway might contribute to the genetics of CHH as causal or modifier mutations and validate the ability of a bioinformatics algorithm on the basis of protein-protein interactome data (interactome-based affiliation scoring [IBAS]) to identify high-quality candidate genes.

TL;DR: Differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis, which may provide a general model for understanding how binding to HS regulates other morphogenetic gradients.