Anders E. Håkansson
University of Copenhagen
12 Papers
108 Citations
Anders E. Håkansson is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Locked nucleic acid & Nucleic acid. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Anders E. Håkansson include Rega Institute for Medical Research.
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Papers
α-l-ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties
Mads D. Sørensen,Lisbet Kværnø,Torsten Bryld,Anders E. Håkansson,Birgit Verbeure,G. Gaubert,Piet Herdewijn,Jesper Wengel +7 more
TL;DR: Binding studies revealed very efficient recognition of single-stranded DNA and RNA target oligonucleotide strands and stereoirregular α-L-LNA 11-mers containing a mixture of α- L-Lna monomers and DNA monomers were shown to display ΔTm values of +1 to +3 °C per modification toward DNA and +4 to +5 °C toward RNA when compared with the corresponding unmodified DNA·DNA and DNA·RNA reference duplexes.
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LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.
Jesper Wengel,Michael Nebeling Petersen,Kathrine E. Nielsen,Gitte A. Jensen,Anders E. Håkansson,Ravindra Kumar,Mads D. Sørensen,Vivek K. Rajwanshi,Torsten Bryld,Jens Peter Jacobsen +9 more
TL;DR: The remarkable binding properties of LNA and α-L-LNA are summarized, and hybridization results for LNA/2′-O-Me-RNA chimera and LNAs with a “dangling” nucleotide are introduced.
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LNA stereoisomers: xylo-LNA (β-D-xylo configured locked nucleic acid) and α-L-LNA (α-L-ribo configured locked nucleic acid)
TL;DR: Oligothymidylate β-D-xylofuranosyl thymine nucleotide monomer α-L-LNA displays strongly enhanced affinity towards complementary RNA.
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High-affinity nucleic acid recognition using ‘LNA’ (locked nucleic acid, β-D-ribo configured LNA), ‘xylo-LNA’ (β-D-xylo configured LNA) or ‘α-L-LNA’ (α-L-ribo configured LNA)
TL;DR: Remarkably strong binding affinities towards complementary single stranded DNA and RNA were obtained for 10- and 14-mer LNAs (locked nucleic acids) containing diastereoisomeric β-D-ribo, β- D-xylo or α-L- ribo configured LNA thymine monomers; a possible relevance of these results in relation to nucleic acid evolution is discussed.
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Convenient Syntheses of 7-Hydroxy-1-(hydroxymethyl)- 3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: α-l-Ribo- and α-l-Xylo-Configured LNA Nucleosides
TL;DR: Synthesis of the diastereoisomeric LNA (locked nucleic acid) nucleosides 1-(2-O,4-C-methylene-alpha-L-ribofuranosyl)thymine and 1-O-p-toluenesulfonyl nucleoside derivatives 3, 7, and 10 are reported via convenient reaction cascades.
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