Amy L. Cavalli
San Diego State University
7 Papers
93 Citations
Amy L. Cavalli is an academic researcher from San Diego State University. The author has contributed to research in topics: Sphingosine-1-phosphate & Sphingosine. The author has an hindex of 6, co-authored 7 publications.
Chat about Author
Papers
Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization
Sergio Caballero,James Stephen Swaney,Kelli Moreno,Aqeela Afzal,Jennifer L. Kielczewski,Glenn L. Stoller,Amy L. Cavalli,William A. Garland,Genevieve Hansen,Roger A. Sabbadini,Maria B. Grant +10 more
TL;DR: It is suggested that neutralizing S1P with anti-S1P mAbs may be a novel method of treating patients with exudative age-related macular degeneration by reducing angiogenesis and sub-retinal fibrosis, which are responsible for visual acuity loss in this disease.
91
Expression and characterization of Edg-1 receptors in rat cardiomyocytes: calcium deregulation in response to sphingosine 1-phosphate.
Nobuko Nakajima,Amy L. Cavalli,Donatella Biral,Christopher C. Glembotski,Patrick M. McDonough,Peter D. Ho,Romeo Betto,Doriana Sandonà,Philip Palade,Christine Dettbarn,Robert Klepper,Roger A. Sabbadini +11 more
TL;DR: Results demonstrate that cardiomyocytes express an extracellular lipid-sensitive receptorsystem that can respond to sphingolipid mediators, and speculate that Edg-mediated Sph1P negative inotropic and cardiotoxic effects may play important roles in acute myocardial ischemia where Sph 1P levels are probably elevated in response to thrombus.
65
Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes.
Amy L. Cavalli,Nicole W. O’Brien,Steven B. Barlow,Romeo Betto,Christopher C. Glembotski,Philip Palade,Roger A. Sabbadini +6 more
TL;DR: Investigation of the expression and function of SCaMPER in cardiomyocytes revealed that it is abundant in cardiac tissue and is localized to the sarcotubular junction, and antisense knockdown of SC aMPER mRNA produced a substantial reduction of sphingolipid-induced calcium release.
21
Patent
Compositions and methods for the treatment and prevention of hyperproliferative diseases
Roger A. Sabbadini,Amy L. Cavalli,William A. Garland +2 more
- 28 Oct 2005
TL;DR: In this article, a combination of monotherapies and combination therapies for treating hyperproliferative disorders are described, as well as compositions for performing such methods and experiments.
11
Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies
Nicole W. O’Brien,S. Tarran Jones,David G. Williams,H. Brad Cunningham,Kelli Moreno,Barbara Visentin,Angela M. Gentile,John A. Vekich,William S. Shestowsky,Masao Hiraiwa,Rosalia Matteo,Amy L. Cavalli,Douglas B. Grotjahn,Maria B. Grant,Genevieve Hansen,Mary Ann Campbell,Roger A. Sabbadini +16 more
TL;DR: The anti-S1P antibody shows promise as a novel, first-in-class therapeutic acting as a “molecular sponge” to selectively deplete S1P from blood and other compartments where pathological S 1P levels have been implicated in disease progression or in disorders where immune modulation may be beneficial.