Alissa C. Rothchild
Seattle Children's Research Institute
32 Papers
115 Citations
Alissa C. Rothchild is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 18, co-authored 28 publications. Previous affiliations of Alissa C. Rothchild include Harvard University & Ragon Institute of MGH, MIT and Harvard.
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Papers
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
Florencia Pereyra,Xiaoming Jia,Paul J. McLaren,Amalio Telenti,de Bakker Pi,Bruce D. Walker,Stephan Ripke,Chanson J. Brumme,Sara L. Pulit,Mary Carrington,Carl M. Kadie,Jonathan M. Carlson,David E. Heckerman,Graham Rr,Robert M. Plenge,Steven G. Deeks,Gianniny L,Gabriel Crawford,Jean C. Sullivan,Elena Gonzalez,Davies L,Amy L. Camargo,Jamie Moore,Beattie N,Soumi Gupta,Crenshaw A,N P Burtt,Candace Guiducci,Namrata Gupta,Gao X,Qi Y,Yuko Yuki,Alicja Piechocka-Trocha,Emily Cutrell,Rachel Rosenberg,Kristin Moss,Lemay P,Jacqueline G. O'Leary,Schaefer T,Verma P,I Tóth,Brian L. Block,Brett Baker,Alissa C. Rothchild,Lian J,Jacqueline Proudfoot,Donna Marie Alvino,Seanna Vine,Marylyn M. Addo,Todd M. Allen,Marcus Altfeld,Matthew R. Henn,Le Gall S,Hendrik Streeck,David W. Haas,Daniel R. Kuritzkes,Gregory K. Robbins,Robert W. Shafer,Roy M. Gulick,Cecilia M. Shikuma,Richard Haubrich,Sharon A. Riddler,Paul E. Sax,Eric S. Daar,Heather J. Ribaudo,Brian K. Agan,Agarwal S,Ryan Ahern,Allen Bl,Altidor S,Altschuler El,Ambardar S,Kathryn Anastos,Brenna L. Anderson,Anderson,Andrady U,Antoniskis D,David R. Bangsberg,Barbaro D,Barrie W,Bartczak J,Barton S,Basden P,Nesli Basgoz,Suzane Bazner,Nicholas Bellos,Benson Am,Judith Berger,Bernard Nf,Bernard Am,Christopher E. Birch,Bodner Sj,Robert K. Bolan,Boudreaux Et,Meg Bradley,Braun Jf,Brndjar Je,Stephen J. Brown,Brown K,Sheldon T. Brown,Burack J,Bush Lm,Cafaro,Campbell O,Justin Campbell,Carlson Rh,Carmichael Jk,Casey Kk,Cavacuiti C,Celestin G,Stephen T. Chambers,Chez N,Lisa M. Chirch,Cimoch Pj,Daniel E. Cohen,Cohn Le,Brian Conway,David A. Cooper,Cornelson B,Cox Dt,Cristofano Mv,Cuchural G,Julie Czartoski,Dahman Jm,Jennifer S. Daly,Benjamin T. Davis,Kenneth L. Davis,Davod Sm,Edwin DeJesus,Craig A. Dietz,Dunham E,Dunn Me,Todd B. Ellerin,J. J. Eron,John Fangman,Farel Ce,Ferlazzo H,Sarah Fidler,Fleenor-Ford A,Frankel R,Kenneth A. Freedberg,French Nk,Jonathan D. Fuchs,Jon Fuller,Gaberman J,Joel E. Gallant,Rajesh T. Gandhi,Garcia E,Garmon D,J. Gathe,Gaultier Cr,Gebre W,Gilman Fd,Gilson I,Paul A. Goepfert,M. S. Gottlieb,Claudia Goulston,Groger Rk,Gurley Td,Haber S,Hardwicke R,W D Hardy,P. R. Harrigan,Trevor Hawkins,Sonya L. Heath,Frederick Hecht,Henry Wk,Hladek M,Hoffman Rp,James Horton,Hsu Rk,Gregory D Huhn,Peter W. Hunt,Hupert Mj,Illeman Ml,Hans Jaeger,Robert M. Jellinger,Mina John,Jennifer Johnson,Kristin Johnson,Johnson H,Kevin M. Johnson,Joly J,Wilbert C. Jordan,Carol A. Kauffman,Khanlou H,Killian Rk,Arthur Y. Kim,Kim Dd,Kinder Ca,Kirchner Jt,Laura Kogelman,Erna M. Kojic,Korthuis Pt,Kurisu W,Douglas S. Kwon,Melissa Lamar,Harry Lampiris,Lanzafame M,Michael M. Lederman,Lee Dm,Lee Jm,Lee Mj,Lee Et,Lemoine J,Jay A. Levy,Josep M. Llibre,Liguori Ma,Susan J. Little,Anne Y. Liu,Lopez Aj,Mona R. Loutfy,Loy D,Mohammed Dy,Man A,Michael K. Mansour,Vincent C. Marconi,Martin Markowitz,R. Marques,Jeffrey N. Martin,Hal Martin,Kenneth H. Mayer,MJ McElrath,McGhee Ta,Barbara H. McGovern,Katherine McGowan,McIntyre D,Mcleod Gx,Menezes P,Mesa G,Craig E. Metroka,Dirk Meyer-Olson,Miller Ao,Montgomery K,Karam Mounzer,Ellen H. Nagami,Nagin I,Nahass Rg,Nelson Mo,Nielsen C,Norene Dl,David H. O’Connor,Bisola O. Ojikutu,Jason F. Okulicz,Oladehin Oo,Oldfield Ec rd,Susan Olender,Mario A. Ostrowski,William F. Owen,Pae E,Parsonnet J,Pavlatos Am,Perlmutter Am,Pierce Mn,Pincus Jm,Pisani L,Price Lj,Laurie A. Proia,Prokesch Rc,Pujet Hc,Moti Ramgopal,Almas Rathod,Rausch M,Ravishankar J,Frank S. Rhame,Richards Cs,Douglas D. Richman,Rodes B,Rodriguez M,Rose Rc rd,Eric S. Rosenberg,Daniel I. Rosenthal,Ross Pe,Diana Rubin,Rumbaugh E,Saenz L,Michelle R Salvaggio,Sanchez Wc,Sanjana Vm,Steven Santiago,Schmidt W,Hanneke Schuitemaker,Sestak Pm,P. Shalit,Shay W,Shirvani Vn,Silebi Vi,Sizemore Jm,Paul R. Skolnik,Marcia Sokol-Anderson,James M. Sosman,Stabile P,Jack T. Stapleton,Starrett S,Stein F,Hans-Jürgen Stellbrink,Sterman Fl,Valerie E. Stone,David Stone,Giuseppe Tambussi,Randy Taplitz,Ellen Tedaldi,Theisen W,Ramon A. Torres,Tosiello L,Cécile Tremblay,Tribble Ma,Trinh Pd,Tsao A,Ueda P,Vaccaro A,Valadas E,Vanig Tj,Vecino I,Vega Vm,Veikley W,Wade Bh,Walworth C,Wanidworanun C,Doug Ward,Warner Da,Rainer Weber,Daniel P. Webster,Weis S,David Wheeler,D. White,Edmund Wilkins,Alan Winston,Wlodaver Cg,van't Wout A,Wright Dp,Otto O. Yang,Yurdin Dl,Zabukovic Bw,Kimon C. Zachary,Zeeman B,Zhao M +336 more
TL;DR: Differences in binding to viral peptide antigens by HLA may be the major factors underlying genetic differences between HIV controllers and progressors, and genome-wide association results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection.
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
Yapeng Su,Daniel Chen,Dan Yuan,Christopher Lausted,Jongchan Choi,Chengzhen L. Dai,Valentin Voillet,Venkata R Duvvuri,Kelsey Scherler,Pamela Troisch,Priyanka Baloni,Guangrong Qin,Brett Smith,Sergey A. Kornilov,Clifford Rostomily,Alexander M. Xu,Jing Li,Shen Dong,Alissa C. Rothchild,Jing Zhou,Kim Murray,Rick Edmark,Sunga Hong,John E. Heath,John C. Earls,Rongyu Zhang,Jingyi Xie,Sarah Li,Ryan Roper,Lesley Jones,Yong Zhou,Lee Rowen,Rachel Liu,Sean Mackay,D. Shane O’Mahony,Christopher R. Dale,Julie A. Wallick,Heather A. Algren,Michael Zager,Wei Wei,Nathan D. Price,Sui Huang,Naeha Subramanian,Kai Wang,Andrew T. Magis,Jenn J. Hadlock,Leroy Hood,Alan Aderem,Jeffrey A. Bluestone,Lewis L. Lanier,Philip D. Greenberg,Raphael Gottardo,Mark M. Davis,Jason D Goldman,James R. Heath +54 more
TL;DR: It is suggested that moderate disease may provide the most effective setting for therapeutic intervention, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes at moderate disease.
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HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition.
Toshiyuki Miura,Mark A. Brockman,Arne Schneidewind,Michael A. Lobritz,Florencia Pereyra,Almas Rathod,Brian L. Block,Zabrina L. Brumme,Chanson J. Brumme,Brett Baker,Alissa C. Rothchild,Bin Li,Alicja Trocha,Alicja Trocha,Emily Cutrell,Nicole Frahm,Christian Brander,Ildiko Toth,Eric J. Arts,Todd M. Allen,Bruce D. Walker,Bruce D. Walker +21 more
TL;DR: A dual mechanism for durable control of HIV replication is suggested, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes.
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In search of a new paradigm for protective immunity to TB
Cláudio Nunes-Alves,Matthew G. Booty,Stephen M. Carpenter,Pushpa Jayaraman,Alissa C. Rothchild,Samuel M. Behar +5 more
TL;DR: Recent advances in the understanding of the immune control of M. tuberculosis are discussed and how this knowledge could be used for vaccine design and evaluation is discussed.
Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes
Toshiyuki Miura,Mark A. Brockman,Chanson J. Brumme,Zabrina L. Brumme,Jonathan M. Carlson,Jonathan M. Carlson,Florencia Pereyra,Alicja Trocha,Alicja Trocha,Marylyn M. Addo,Brian L. Block,Alissa C. Rothchild,Brett Baker,Theresa Flynn,Arne Schneidewind,Bin Li,Yaoyu E. Wang,David Heckerman,Todd M. Allen,Bruce D. Walker,Bruce D. Walker +20 more
TL;DR: Viral sequencing from 95 HIV-1 elite controllers who maintained plasma viral loads of <50 RNA copies/ml in the absence of therapy indicated the spontaneous control of HIV replication is not attributable to shared viral genetic defects or shared viral polymorphisms.