The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

Factor viii compositions and methods of making and using same

The present disclosure relates to a blow-molded, rigid collapsible liner that can be suitable particularly for smaller storage and dispensing systems. The rigid collapsible liner may be a stand-alone liner, e.g., used without an outer container, and may be dispensed from a fixed pressure dispensing can. Folds in the rigid collapsible liner may be substantially eliminated, thereby substantially reducing or eliminating the problems associated with pinholes, weld tears, and overflow. The present disclosure also relates to systems and liners, including the liners just mentioned, that may be used as alternatives to, or replacements for, simple rigid- wall containers, such as those made of glass. Such advantageous systems and liners may replace simple rigid-wall containers in a system for delivering a high purity material to a semiconductor process substantially without modification to an end user's existing pump dispense or pressure dispense systems.

Substantially rigid collapsible liner, container and/or liner for replacing glass bottles, and enhanced flexible liners

The present disclosure relates to an integrated liner-based system having an overpack and a liner provided within the overpack, the liner comprising a mouth and a liner wall forming an interior cavity of the liner and having a thickness such that the liner is substantially self-supporting in an expanded state, but is collapsible at a pressure of less than about 20 psi. The liner and overpack may be made by blow molding the liner and the overpack at the same time using nested preforms.

Nested blow molded liner and overpack and methods of making same

Provided are recombinant Factor VIII proteins, e.g., human Factor VIII proteins with heterologous moieties inserted into flexible permissive loops located in the Factor VIII A domains, while retaining the procoagulant activity of Factor VIII.

Recombinant Factor VIII proteins

A liner having a tubular body portion with a top circumferential edge and a bottom circumferential edge, a generally circular bottom portion sealed to the tubular body portion along the bottom circumferential edge, and a generally circular top portion sealed to the tubular body portion along the top circumferential edge. The top portion may include a fitment sealed thereto. The tubular body portion may include at least one weld seam extending from the top circumferential edge to the bottom circumferential edge. In a particular embodiment, the tubular body portion may include two sheets welded together to form a tubular body, the tubular body portion thus having two weld seams extending from the top circumferential edge to the bottom circumferential edge.

Generally cylindrically-shaped liner for use in pressure dispense systems and methods of manufacturing the same

The present disclosure, in one embodiment, relates to a liner-based assembly having an overpack and a liner disposed within the overpack. The liner may be formed by blow molding a liner preform within the overpack to form a blow molded liner substantially conforming to the interior of the overpack and generally forming an interface with an interior of the overpack. The present disclosure, in another embodiment, relates to a liner-based assembly including a blow-molded overpack comprised of polyethylene terephthalate, a blow-molded liner disposed within the overpack, the liner comprised of a polymer material, wherein the overpack and liner have a combined wall thickness of about 0.3 mm or less, and a base cup configured to at least partially surround an exterior of the overpack. In some embodiments, the liner has a volume of up to about 4.7 liters and an empty weight of between about 260-265 grams.

Liner-based shipping and dispensing systems

A method for removing headspace gas from a liner-based assembly. The liner-based assembly may generally include an overpack, a liner positioned within the overpack and containing a material and headspace gas, and a closure for sealing the liner. The method may include providing a one-way valve in fluid communication with the interior of the liner and permitting flow in a direction out of the interior of the liner, and applying a vacuum to the one-way valve to evacuate headspace gas from the interior of the liner. In some embodiments, The liner-based assembly may also include a port in fluid communication with an annular space between the overpack and liner, and the method may include capping the port, for example, during application of the vacuum to the one-way valve.

Closure/connectors for liner-based shipping and dispensing containers and methods for filling liner-based shipping and dispensing containers

The present disclosure relates to storage, transportation, and/or dispense packaging systems, and particularly container-based or liner-based storage, transportation, and/or dispensing systems, such as but not limited to bottle systems, drum systems, bag-in-bottle (BIB) systems, bag-in-drum systems, or the like for use in any suitable dispense application.

Storage, transportation, and/or dispense packaging

The invention relates to a method of forming liner-based liner-based assembly, and a liner-based system The present disclosure, in one embodiment, relates to a liner-based assembly having an overpack and a liner disposed within the overpack The liner may be formed by blow molding a liner preform within the overpack to form a blow molded liner substantially conforming to the interior of the overpack and generally forming an interface with an interior of the overpack The present disclosure, in another embodiment, relates to a liner-based assembly including a blow-molded overpack comprised of polyethylene terephthalate, a blow-molded liner disposed within the overpack, the liner comprised of a polymer material, wherein the overpack and liner have a combined wall thickness of about 03 mm or less, and a base cup configured to at least partially surround an exterior of the overpack

Method of forming liner-based liner-based assembly, and liner-based system

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Liner-based shipping and dispensing systems

Closure/connectors for liner-based shipping and dispensing containers and methods for filling liner-based shipping and dispensing containers

Storage, transportation, and/or dispense packaging

Method of forming liner-based liner-based assembly, and liner-based system