Alberto Bresciani
Merck & Co.
53 Papers
158 Citations
Alberto Bresciani is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 12, co-authored 43 publications.
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Papers
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis
Alessio Reggio,Marco Rosina,Alessandro Palma,Andrea Cerquone Perpetuini,Lucia Lisa Petrilli,Cesare Gargioli,Claudia Fuoco,Elisa Micarelli,Giulio Giuliani,Mauro Cerretani,Alberto Bresciani,Francesca Sacco,Luisa Castagnoli,Gianni Cesareni +13 more
TL;DR: FAPs are characterized as the main source of WNT ligands inferring their potential in mediating autocrine/paracrine responses in the muscle niche, and WNT5a, whose expression is impaired in dystrophic FAPs, is identified as a crucial W NT ligand able to restrain the detrimental adipogenic differentiation drift of these cells through the positive modulation of the β-catenin signaling.
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Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
Lorenzo Turcano,Esther Torrente,Antonino Missineo,Matteo Andreini,Marina Gramiccia,Trentina Di Muccio,Ilaria Genovese,Annarita Fiorillo,Steven J. Harper,Alberto Bresciani,Gianni Colotti,Andrea Ilari +11 more
TL;DR: In order to identify new lead compounds against Leishmania, a new luminescence-based high-throughput screening (HTS) assay was developed and validated that allowed us to screen a library of 120,000 compounds and identified a novel chemical class of TR inhibitors, able to kill parasites with an IC50 in the low micromolar range.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Alberto Bresciani,Antonino Missineo,Mariana Gallo,Mauro Cerretani,Paola Fezzardi,Licia Tomei,Daniel O. Cicero,Sergio Altamura,Alessia Santoprete,Raffaele Ingenito,Elisabetta Bianchi,Robert Pacifici,Celia Dominguez,Ignacio Munoz-Sanjuan,Steven J. Harper,Leticia Toledo-Sherman,Larry Park +16 more
TL;DR: A set of new, robust and informative biochemical assays that enable the selection and optimization of non-covalent KEAP1 binders are described, including a time-resolved fluorescence resonance energy transfer (TR-FRET) primary assay with high modularity and robustness.
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Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
Alberto Bresciani,Maria Carolina Spiezia,Roberto Boggio,Cristina Cariulo,Anja Nordheim,Roberta Altobelli,Kirsten Kuhlbrodt,Celia Dominguez,Ignacio Munoz-Sanjuan,John Wityak,Valentina Fodale,Deanna Marchionini,Andreas Weiss +12 more
TL;DR: A novel set of LC3B-II and p62 time-resolved fluorescence resonance energy transfer (TR-FRET) assays that can detect changes in autophagy in the absence of exogenous labels are described and demonstrate that different cells exhibit varying autophagic responses to pharmacological interventions.
Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.
Jesus Maria Ontoria Ontoria,Giacomo Paonessa,Simona Ponzi,Federica Ferrigno,Emanuela Nizi,Ilaria Biancofiore,Savina Malancona,Rita Graziani,David Roberts,Paul Willis,Alberto Bresciani,Nadia Gennari,Ottavia Cecchetti,Edith Monteagudo,Maria Vittoria Orsale,Maria Veneziano,Annalise Di Marco,Antonella Cellucci,Ralph Laufer,Sergio Altamura,Vincenzo Summa,Steven J. Harper +21 more
TL;DR: Inhibition of parasital HDACs as the mechanism of action of this new class of selective growth inhibitors is supported by hyperacetylation studies.
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