Albert O. Edwards
University of Oregon
113 Papers
1.7K Citations
Albert O. Edwards is an academic researcher from University of Oregon. The author has contributed to research in topics: Macular degeneration & Genome-wide association study. The author has an hindex of 44, co-authored 112 publications. Previous affiliations of Albert O. Edwards include Wills Eye Institute & University of Illinois at Chicago.
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Papers
Complement Factor H Polymorphism and Age-Related Macular Degeneration
Albert O. Edwards,Robert C. Ritter,Kenneth Abel,Alisa K. Manning,Carolien I.M. Panhuysen,Lindsay A. Farrer +5 more
TL;DR: In this paper, single-nucleotide polymorphisms were tested for association with AMD in two independent case-control populations and significant association was identified within the regulation of complement activation locus and was centered over a tyrosine-402 --> histidine-402 protein polymorphism in the gene encoding complement factor.
2.4K
Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups.
Albert O. Edwards,Holly A. Hammond,Li Jin,C. Thomas Caskey,C. Thomas Caskey,Ranajit Chakraborty +5 more
TL;DR: The results suggest that trimeric and tetrameric STR loci are useful markers for the study of new mutations and genetic linkage analysis and for application to personal identification in the medical and forensic sciences.
1.5K
Automated DNA sequencing of the human HPRT locus
Albert O. Edwards,H. Voss,P Rice,Civitello Ab,J. Stegemann,Christian Schwager,Jürgen Zimmermann,Holger Erfle,Charles T. Caskey,Wilhelm Ansorge +9 more
TL;DR: The complete sequence of 57 kb of the human HPRT locus has been determined using automated fluorescent DNA sequencing using M13 (universal and reverse) and custom oligonucleotide primers.
373
Transcriptome analysis and molecular signature of human retinal pigment epithelium
N.V. Strunnikova,Arvydas Maminishkis,Jennifer J. Barb,F. Wang,C. Zhi,Yuri V. Sergeev,Wei Chen,Albert O. Edwards,Dwight Stambolian,Gonçalo R. Abecasis,Anand Swaroop,Peter J. Munson,Sheldon S. Miller +12 more
TL;DR: The RPE signature gene set should allow the validation of RPE-like cells derived from human embryonic or induced pluripotent stem cells for cell-based therapies of degenerative retinal diseases and for physiological investigations (e.g. dopachrome tautomerase in melanogenesis).
E2-2 Protein and Fuchs's Corneal Dystrophy
Keith H. Baratz,Nirubol Tosakulwong,Euijung Ryu,William L. Brown,Kari Branham,Wei Chen,Khoa D. Tran,Katharina E. Schmid-Kubista,John R. Heckenlively,Anand Swaroop,Gonçalo R. Abecasis,Kent R. Bailey,Albert O. Edwards +12 more
TL;DR: Genetic variation in TCF4 contributes to the development of FCD and is associated with typical and advanced FCD.