Alan L. Rothman
University of Rhode Island
188 Papers
1.5K Citations
Alan L. Rothman is an academic researcher from University of Rhode Island. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 68, co-authored 177 publications. Previous affiliations of Alan L. Rothman include University of Massachusetts Medical School & University of Massachusetts Amherst.
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Papers
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
1.7K
Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
TL;DR: An increased understanding of the adaptive immune response to natural d Dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengued infection.
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
Daniel H. Libraty,Paul R. Young,Darren Pickering,Timothy P. Endy,Siripen Kalayanarooj,Sharone Green,David W. Vaughn,Ananda Nisalak,Francis A. Ennis,Alan L. Rothman +9 more
TL;DR: In this paper, the secreted dengue virus nonstructural protein NS1 (sNS1) was measured daily in 32 children with Dengue-2 virus infections participating in a prospective, hospital-based study.
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Early Clinical and Laboratory Indicators of Acute Dengue Illness
Siripen Kalayanarooj,David W. Vaughn,S. Nimmannitya,Sharone Green,Saroj Suntayakorn,N. Kunentrasai,W. Viramitrachai,S. Ratanachu-eke,S. Kiatpolpoj,Bruce L. Innis,Alan L. Rothman,A. Nisalak,Francis A. Ennis +12 more
TL;DR: Simple clinical and laboratory parameters are identified that help to identify children with DF or DHF, including plasma AST levels were higher in children who developed DHF than in those with DF.
704
Differing Influences of Virus Burden and Immune Activation on Disease Severity in Secondary Dengue-3 Virus Infections
Daniel H. Libraty,Timothy P. Endy,Huo-Shu H. Houng,Sharone Green,Siripen Kalayanarooj,Saroj Suntayakorn,Wanya Chansiriwongs,David W. Vaughn,Ananda Nisalak,Francis A. Ennis,Alan L. Rothman +10 more
TL;DR: Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections.
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