Alain Commercon
Aventis Pharma
161 Papers
2.1K Citations
Alain Commercon is an academic researcher from Aventis Pharma. The author has contributed to research in topics: Alkyl & Aryl radical. The author has an hindex of 25, co-authored 161 publications. Previous affiliations of Alain Commercon include Rhône-Poulenc & Université Paul Cézanne Aix-Marseille III.
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Papers
Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Patricia Vrignaud,Dorothée Semiond,Pascale Lejeune,Herve Bouchard,Loreley Calvet,Cecile Combeau,Jean-François Riou,Alain Commercon,François Lavelle,Marie-Christine Bissery +9 more
TL;DR: Cabazitaxel is as active as docetaxel in docentaxel-sensitive tumor models but is more potent than docetAXel in tumor models with innate or acquired resistance to taxanes and other chemotherapies.
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Improved protection and esterification of a precursor of the taxotere® and taxol side chains
TL;DR: In this paper, the N-deprotected intermediates of Taxotere® and taxol were obtained by smoothing formic acid with baccatins, which did not generate any epimerization at C-2′ and constitutes a pratical method to prepare taxotere®, taxol and analogs.
159
Patent
Novel taxoids, preparation thereof and pharmaceutical compositions containing same
Herve Bouchard,Jean-Dominique Bourzat,Alain Commercon +2 more
- 25 Mar 1996
TL;DR: In this article, the preparation of novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing them are described, wherein Z is a hydrogen atom or a radical of general formulas (II), wherein R1 is an optionally substituted benzoyl radical or a Radical R2-O-CO- where R2 is an alternatively substituted phenyl, alkyl, alkenyl, alkynyl, cycloalkyl and cyclo-alkenyl.
159
Patent
Taxoids, their preparation and pharmaceutical compositions containing them
Herve Bouchard,Jean Dominique Bourzat,Alain Commercon +2 more
- 07 Jun 1995
TL;DR: In this article, the preparation of novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed and the novel taxoid properties are analyzed.
134
Patent
Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
Laurence Gauzy,Robert Yongxin Zhao,Deng Yonghong,Wei Li,Herve Bouchard,Ravi V. J. Chari,Alain Commercon +6 more
- 22 Jan 2007
TL;DR: The present invention is related to new tomaymycin of formula (I) derivatives, their process of preparation and their therapeutic uses as discussed by the authors, and their use in medical applications.
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