Akiko Ueno
Osaka University
5 Papers
Akiko Ueno is an academic researcher from Osaka University. The author has contributed to research in topics: Chemistry & Retina. The author has an hindex of 5, co-authored 5 publications.
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Papers
Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors
Cesare Orlandi,Yoshihiro Omori,Yuchen Wang,Yan Cao,Akiko Ueno,Michel Roux,Giuseppe Condomitti,Joris de Wit,Motoi Kanagawa,Takahisa Furukawa,Kirill A. Martemyanov +10 more
TL;DR: It is demonstrated that the HSPG member Pikachurin, released by photoreceptors, recruits a key post-synaptic signaling complex of downstream ON-bipolar neurons in coordination with the presynaptic dystroglycan glycoprotein complex, and plays an essential role in synaptic transmission of photoreceptor signals.
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Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport *
Meriam Boubakri,Taro Chaya,Taro Chaya,Hiromi Hirata,Naoko Kajimura,Ryusuke Kuwahara,Akiko Ueno,Jarema Malicki,Takahisa Furukawa,Yoshihiro Omori,Yoshihiro Omori +10 more
TL;DR: Results show that IFT-A is essential for the efficient transport of outer segment proteins, including opsin, and for the survival of retinal photoreceptor cells, rendering the ift122 mutant a unique model for human retinal degenerative diseases.
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Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells
TL;DR: The current understanding of the key factors and mechanisms underlying selective synapse formation of photoreceptor cells with bipolar and horizontal cells in the retina are reviewed and how defects/mutations of the molecules involved in Photoreceptor synapses formation are associated with human retinal diseases and visual disorders are described.
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Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity
Yoshihiro Omori,Shun Kubo,Tetsuo Kon,Mayu Furuhashi,Hirotaka Narita,Taro Kominami,Akiko Ueno,Ryotaro Tsutsumi,Taro Chaya,Haruka Yamamoto,Isao Suetake,Shinji Ueno,Haruhiko Koseki,Atsushi Nakagawa,Takahisa Furukawa +14 more
TL;DR: The current study suggests that Samd7 is a cell type-specific PRC1 component epigenetically defining rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod Photoreceptor cells.
Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity
Akiko Ueno,Yoshihiro Omori,Yuko Sugita,Satoshi Watanabe,Taro Chaya,Takashi Kozuka,Tetsuo Kon,Satoyo Yoshida,Kenji Matsushita,Ryusuke Kuwahara,Naoko Kajimura,Yasushi Okada,Takahisa Furukawa +12 more
TL;DR: It is found that Lrit1, a leucine-rich transmembrane protein, localizes to the photoreceptor synaptic terminal and regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells.