Akiko Iwata
Fred Hutchinson Cancer Research Center
32 Papers
303 Citations
Akiko Iwata is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Reperfusion injury & Ischemia. The author has an hindex of 11, co-authored 32 publications. Previous affiliations of Akiko Iwata include University of Washington.
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Papers
Adeno-associated virus vector transduction of vascular smooth muscle cells in vivo.
Matthias Richter,Akiko Iwata,John Nyhuis,Yoshio Nitta,A. Dusty Miller,Christine L. Halbert,Margaret D. Allen +6 more
TL;DR: It is demonstrated that AAV is a promising vector for intravascular applications in coronary and peripheral vascular diseases through transduction of vascular cell transduction in an in vivo rabbit carotid artery model.
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Liposome-Mediated Gene Transfection of Endothelial Nitric Oxide Synthase Reduces Endothelial Activation and Leukocyte Infiltration in Transplanted Hearts
Akiko Iwata,Sadahiro Sai,Yoshio Nitta,Megan Chen,Ricarda de Fries-Hallstrand,Joy Dalesandro,Robert Thomas,Margaret D. Allen +7 more
TL;DR: Intraoperative liposome-mediated gene delivery of eNOS to donor hearts can result in early gene expression sufficient to reduce ischemia-reperfusion injury by inhibiting NF-&kgr;B activation, adhesion molecule expression, and the early infiltration of leukocytes, all of which may improve graft survival.
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A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model.
TL;DR: This work investigates the effect of the broad-spectrum caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (z-VAD-fmk), on airway inflammation in OVA-sensitized/challenged mice and proposes that casp enzyme inhibitors may offer a novel therapeutic approach to T cell-dependent inflammatory airway diseases.
52
The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials
TL;DR: It is shown for the first time that caspase inhibitors are effective when CD18 blockade is not and that all preclinical investigations of I/R must be evaluated with increasing ischemia if they are to model the clinical disease.
44
Jagged1 Suppresses Collagen-Induced Arthritis by Indirectly Providing a Negative Signal in CD8(+) T Cells
Mika Kijima,Akiko Iwata,Yoichi Maekawa,Hisanori Uehara,Keisuke Izumi,Akiko Kitamura,Hideo Yagita,Shigeru Chiba,Hiroshi Shiota,Koji Yasutomo +9 more
TL;DR: Data indicate that Jagged1 is able to deliver an indirect negative signal into CD8+ T cells in vivo, which suggests its therapeutic potential in the treatment of CD8- T cell-mediated diseases, including rheumatoid arthritis.