Adam M. Benham

TL;DR: Findings reveal that ADAM3 requires testis-specific private chaperones to be folded properly and that the principle role of ADAM2 is for sperm migration into the oviduct but not for the fertilization event, and the importance of primary sperm ZP binding should be reconsidered.

TL;DR: This work shows that Calr3−/− males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida, and establishes the client specificity of CALR3.

TL;DR: It is shown that cells treated with lactacystin fail to present influenza antigens to influenza‐specific CTL, but retain the capacity to present defined epitopes expressed as peptides intracellularly by recombinant vaccinia viruses, demonstrating that proteasome‐dependent degradation plays an important role in the cytosolic generation of CTL epitopes.

TL;DR: Ero1‐Lα, the human homolog of Ero1p, exists as a collection of oxidized and reduced forms and covalently binds PDI, and the results demonstrate that this motif is important for protein folding, structural integrity, protein half‐life and the stability of the Ero 1‐L α–PDI complex.