Chinnaswamy Jagannath

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is shown that Toll-like receptor 4 (TLR4) served as a previously unrecognized environmental sensor for autophagy, and a new molecular pathway in which LPS-induced Autophagy was regulated through a Toll-interleukin-1 receptor domain-containing adaptor-inducing interferon-beta (TRIF)-dependent, myeloid differentiation factor 88 (MyD88)-independent TLR4 signaling pathway was defined.

TL;DR: It is found that rapamycin-induced autophagy enhanced Ag85B presentation by APCs infected with wild-type Mycobacterium tuberculosis H37Rv, H37 Rv-derived ΔfbpA attenuated candidate vaccine or BCG and enhanced immunogenicity in mice, suggesting that vaccine efficacy can be enhanced by augmenting Autophagy-mediated antigen presentation.

TL;DR: The targeted disruption of two genes encoding mycolyl transferase and fibronectin-binding activities in M. tuberculosis will permit the systematic determination of their roles in the physiology and pathogenesis of this organism.