About: VWA2 is a research topic. Over the lifetime, 4 publications have been published within this topic receiving 47 citations. The topic is also known as: AMACO & CCSP-2.
TL;DR: A detailed mass spectrometric analysis of AMACO shows that both elongated O-glucosylated (Xyl1–3Xyl 1–3Glc) and shortened O-fucosyated glycan chains (NeuAc2–3Gal1–4GlcNAc1-3Fuc) can be attached to AMACo in close proximity on the same epidermal growth factor-like domain.
TL;DR: It is shown by immunogold electron microscopy of mouse kidney and skin that AMACO does not occur within the basement membranes but rather subjacent to the basement membrane at its stromal surface, suggesting that cell adhesion is not AMACo's major function.
TL;DR: In this article, the authors show that AMACO deposition is lost in Fras1-deficient zebrafish and mice and that fras1 and AMACo interact directly via their chondroitin sulfate proteoglycan (CSPG) and P2 domains.
TL;DR: In situ hybridization revealed that the muscle precursor cells of the somites express the protein that is laid down in the myosepta, and RT-PCR shows strongest AMACO expression during development, starting at the 5 somite stage.