Topic
Vortex mixer
About: Vortex mixer is a research topic. Over the lifetime, 107 publications have been published within this topic receiving 1775 citations.
Papers published on a yearly basis
Papers
TL;DR: In this article, a multi-inlet vortex mixer (MIVM) is proposed to control both the supersaturation and the final solvent quality by varying stream velocities.
396 citations
TL;DR: The original CIJ design was modified to allow hand operation, eliminating the need for a syringe pump, and a second antisolvent dilution stage was added, resulting in a simple, cheap, and efficient device to produce nanoparticles.
179 citations
TL;DR: In this article, a multi-inlet vortex mixer (MIVM) was used for flash nanoprecipitation using β-Carotene and polyethyleneimine (PEI) encapsulated in diblock copolymers.
Abstract: We present an experimental study of self-assembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). β-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO3)3) and potassium thiocyanate (KSCN) to precipitate Fe(SCN)
(3−)+
. Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flow-pattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.
116 citations
TL;DR: In this article, the authors describe a vortex T-mixer that generates mixing-inducing flows even at low Reynolds numbers as compared to a simple Tmixer with tangentially aligned inlet channels.
97 citations
TL;DR: An automated grinding method based on a vortex mixer that enables simultaneous grinding and UV-irradiation, as well as in situ monitoring of solid-state reactivity, has been developed.
90 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 5 |
| 2019 | 6 |
| 2018 | 8 |
| 2017 | 9 |
| 2016 | 7 |