Topic
Viroid
About: Viroid is a research topic. Over the lifetime, 1531 publications have been published within this topic receiving 45521 citations. The topic is also known as: viroids.
Papers published on a yearly basis
Papers
TL;DR: Viroids are uncoated infectious RNA molecules pathogenic to certain higher plants and exhibit high thermal stability, cooperativity, and self-complementarity resulting in a rod-like native structure.
Abstract: Viroids are uncoated infectious RNA molecules pathogenic to certain higher plants. Four different highly purified viroids were studied. By ultracentrifugation, thermal denaturation, electron microscopy, and end group analysis the following features were established: (i) the molecular weight of cucumber pale fruit viroid from tomato is 110,000, of citrus exocortis viroid from Gynura 119,000, of citrus exocortis viroid from tomato 119,000 and of potato spindle tuber viroid from tomato 127,000. (ii) Viroids are single-stranded molecules. (iii) Virods exhibit high thermal stability, cooperativity, and self-complementarity resulting in a rod-like native structure. (iv) Viroids are covalently closed circular RNA molecules.
2,119 citations
TL;DR: These findings demonstrate that a mechanism of de novo methylation of genes might exist that can be induced and targeted in a sequence-specific manner by their own mRNA.
1,008 citations
TL;DR: The viroid of the potato spindle tuber disease is a covalently closed ring of 359 ribonucleotides that is the first pathogen of a eukaryotic organism for which the complete molecular structure has been established.
Abstract: The viroid of the potato spindle tuber disease (PSTV) is a covalently closed ring of 359 ribonucleotides. As a result of intramolecular base pairing, a serial arrangement of double-helical sections and internal loops form a unique rod-like secondary structure. PSTV is the first pathogen of a eukaryotic organism for which the complete molecular structure has been established.
484 citations
TL;DR: Although they induce symptoms in plants similar to those accompanying virus infections, viroids have unique structural, functional, and evolutionary characteristics and could exert their pathogenic effects via RNA silencing.
Abstract: Although they induce symptoms in plants similar to those accompanying virus infections, viroids have unique structural, functional, and evolutionary characteristics. They are composed of a small, nonprotein-coding, single-stranded, circular RNA, with autonomous replication. Viroid species are clustered into the families Pospiviroidae and Avsunviroidae, whose members replicate (and accumulate) in the nucleus and chloroplast, respectively. Viroids replicate in three steps through an RNA-based rolling-circle mechanism: synthesis of longer-than-unit strands catalyzed by host RNA polymerases; processing to unit-length, which in the family Avsunviroidae is mediated by hammerhead ribozymes; and circularization. Within the initially infected cells, viroid RNA must move to its replication organelle, with the resulting progeny then invading adjacent cells through plasmodesmata and reaching distal parts via the vasculature. To carry out these movements, viroids must interact with host factors. The mature viroid RNA ...
470 citations
TL;DR: An analysis of total plant RNA sequences using Life Sciences 454 high-throughput sequencing revealed that a vine showing decline symptoms supported a mixed infection that included seven different RNA genomes.
370 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 29 |
| 2024 | 55 |
| 2023 | 52 |
| 2022 | 150 |
| 2021 | 38 |
| 2020 | 40 |