Topic
Vasicine
About: Vasicine is a research topic. Over the lifetime, 201 publications have been published within this topic receiving 2711 citations. The topic is also known as: (±)-vasicine & (±)-peganine.
Papers published on a yearly basis
Papers
TL;DR: The alkaloid was found to be identical with 2,3-(α-hydroxytrimethylene)-4 quinazolone which had been prepared earlier by the oxidation of vasicine with 30 per cent hydrogen peroxide1,2.
Abstract: A NEW alkaloid has been isolated by us in the crystalline form from the leaves of Adhatoda vasica Nees (Indian Patent No. 62349 of November 21, 1957. Patent application No. 64603 of July 9, 1958). The alkaloid, which has been named vasicinone, has been found to be a much weaker base than vasicine, an alkaloid which is already known to be present in this plant. Elementary analysis gave, C = 65.33, H = 4.93, N = 13.65 per cent. The molecular weight (Rast) was found to be about 210 and the molecular formula C11H10N2O2. The alkaloid was found to be identical with 2,3-(α-hydroxytrimethylene)-4 quinazolone which had been prepared earlier by the oxidation of vasicine with 30 per cent hydrogen peroxide1,2.
203 citations
TL;DR: This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of P. harmala, which has antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects.
Abstract: Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, harmine, harmalol, harman, quinazoline derivatives, vasicine, vasicinone, anthroquinons and fixed oils are reported from seeds and roots of this plant. This plant is used as a medicine in Turkey, Syria, Iran, Pakistan, India, Egypt and Spain. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of P. harmala.
Key words: Peganum harmala, zygophyllaceae, phytochemical, pharmacological properties.
148 citations
TL;DR: The results suggest a use of the extract of A. vasica as an antidiabetic agent and show a possibility that compounds 1 and 2 could be an useful treatment for metabolic disorders.
136 citations
97 citations
72 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 11 |
| 2019 | 8 |
| 2018 | 8 |
| 2017 | 10 |
| 2016 | 19 |