Topic
Valine
About: Valine is a research topic. Over the lifetime, 8144 publications have been published within this topic receiving 216230 citations. The topic is also known as: L-Val & (2S)-2-Amino-3-methylbutanoic acid.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Abstract: Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics) We investigated whether metabolite profiles could predict the development of diabetes Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tandem mass spectrometry (LC-MS) Cases and controls were matched for age, body mass index and fasting glucose Five branched-chain and aromatic amino acids had highly significant associations with future diabetes: isoleucine, leucine, valine, tyrosine and phenylalanine A combination of three amino acids predicted future diabetes (with a more than fivefold higher risk for individuals in top quartile) The results were replicated in an independent, prospective cohort These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment
2,954 citations
TL;DR: A single amino acid substitution appears to be sufficient to confer transforming properties on the gene product of the T24 human bladder carcinoma oncogene.
Abstract: The genetic change that leads to the activation of the oncogene in T24 human bladder carcinoma cells is shown to be a single point mutation of guanosine into thymidine. This substitution results in the incorporation of valine instead of glycine as the twelfth amino acid residue of the T24 oncogene-encoded p21 protein. Thus, a single amino acid substitution appears to be sufficient to confer transforming properties on the gene product of the T24 human bladder carcinoma oncogene.
1,277 citations
TL;DR: The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.
Abstract: When plasma tryptophan is elevated by the injection of tryptophan or insulin, or by the consumption of carbohydrates, brain tryptophan and serotonin also rise; however, when even larger elevations of plasma tryptophan are produced by the ingestion of protein-containing diets, brain tryptophan and serotonin do not change. The main determinant of brain tryptophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids (that is, tyrosine, phenylalanine, leucine, isoleucine, and valine) that compete with it for uptake into the brain.
1,168 citations
TL;DR: The aliphatic index of proteins of thermophilic bacteria is significantly higher than that of ordinary proteins and may be regarded as a positive factor for the increase of thermostability of globular proteins.
Abstract: A statistical analysis shows that the aliphatic index, which is defined as the relative volume of a protein occupied by aliphatic side chains (alanine, valine, isoleucine, and leucine), of proteins of thermophilic bacteria is significantly higher than that of ordinary proteins. The index may be regarded as a positive factor for the increase of thermostability of globular proteins.
1,141 citations
TL;DR: In this paper, the authors measured 20 plasma amino acids measured in obese subjects compared with age and sex-matched controls and found that these were the amino acids most sensitive to the action of insulin in lowering plasma amino acid levels.
Abstract: Of 20 plasma amino acids measured, valine, leucine, isoleucine, tyrosine and phenylalanine were increased, and glycine decreased, in obese subjects compared with age- and sex-matched controls The concentration of each of the amino acids elevated in obesity correlated directly with serum insulin In addition, these were the amino acids most sensitive to the action of insulin in lowering plasma amino acid levels, as evidenced by a diminution in concentration after glucose infusion Despite a significantly greater increment in serum insulin in the obese group, the magnitude of the decline in amino acids after glucose administration was identical in the two groups Hyperaminoacidemia appears to be a manifestation of the insulin ineffectiveness characteristic of obesity Furthermore, hyperaminoacidemia may provide the feedback signal to the beta cell through which insulin resistance is accompanied by an appropriately augmented secretory rate of insulin
798 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 1 |
| 2025 | 105 |
| 2024 | 160 |
| 2023 | 301 |
| 2022 | 519 |
| 2021 | 150 |