Topic
TXNIP
About: TXNIP is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 35836 citations. The topic is also known as: upregulated by 1,25-dihydroxyvitamin D-3 & thioredoxin-interacting protein.
Papers published on a yearly basis
Papers
TL;DR: The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1β in the pathogenesis of type 2 diabetes.
Abstract: The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with several inflammatory diseases, yet little is known about the signaling pathways that lead to its activation. Here we show that NLRP3 interacted with thioredoxin (TRX)-interacting protein (TXNIP), a protein linked to insulin resistance. Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. TXNIP deficiency impaired activation of the NLRP3 inflammasome and subsequent secretion of interleukin 1beta (IL-1beta). Akin to Txnip(-/-) mice, Nlrp3(-/-) mice showed improved glucose tolerance and insulin sensitivity. The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes.
2,492 citations
TL;DR: It is proposed that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
Abstract: Interleukin-1β (IL-1β), reactive oxygen species (ROS), and thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1β production and its pathogenic role in islet dysfunction during chronic hyperglycemia. In doing so, we integrate previously disparate disease-driving mechanisms for IL-1β, ROS, and TXNIP in T2DM into one unifying model in which the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives IL-1β maturation and secretion in another disease of metabolic dysregulation, gout. Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
1,100 citations
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.
779 citations
TL;DR: The results suggested that TBP-2/VDUP1 serves as a negative regulator of the biological function and expression of TRX, an important redox regulatory mechanism in cellular processes, including differentiation of myeloid and macrophage lineages.
759 citations
TL;DR: It is reported that thioredoxin-interacting protein (TXNIP) is a critical signaling node that links ER stress and inflammation and is a potential therapeutic target for diabetes and ER stress-related human diseases such as Wolfram syndrome.
656 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 46 |
| 2024 | 82 |
| 2023 | 135 |
| 2022 | 205 |
| 2021 | 180 |
| 2020 | 166 |