Topic
Triethylphosphite
About: Triethylphosphite is a research topic. Over the lifetime, 251 publications have been published within this topic receiving 2547 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: The peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality.
Abstract: α-Amino acid thiol esters derived from N-protected mono-, di-, and tripeptides couple with aryl, π-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric Cu(I) thiophene-2-carboxylate and catalytic Pd2(dba)3/triethylphosphite to generate the corresponding N-protected peptidyl ketones in good-to-excellent yields and in high enantiopurity. Triethylphosphite plays a key role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation−β-elimination of the α-amino thiol esters. The peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality.
131 citations
TL;DR: A novel palladium-catalyzed synthesis of arylphosphonates from arenediazonium tetrafluoroborates and triethylphosphite or diethylph phosphite is presented.
Abstract: A novel palladium-catalyzed synthesis of arylphosphonates from arenediazonium tetrafluoroborates and triethylphosphite or diethylphosphite is presented. The reaction tolerates useful substituents including bromo, chloro, nitro, ether, cyano, keto, and ester groups, can be performed as a one-pot process from anilines omitting the isolation of arenediazonium salts, and can be extended to the preparation of arylphosphine oxides and arylphosphines.
78 citations
TL;DR: In this paper, the behavior of the [Ru2(CO)4(CH3COO)2]n/tributylphosphine/acetic acid system has been investigated as a function of reaction conditions and molar ratios of reactants.
75 citations
TL;DR: In this article, a fully benzoylated phenylsulfenyl glycoside with acceptors under the agency of trimethylsilyl triflate proceeds with a good degree of chemoselectivity in the presence of scavenger triethylphosphite.
65 citations
TL;DR: In this article, the peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality, and triethylphosphite plays a key role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation−β-elimination of the α-amino thiol esters.
Abstract: α-Amino acid thiol esters derived from N-protected mono-, di-, and tripeptides couple with aryl, π-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric Cu(I) thiophene-2-carboxylate and catalytic Pd2(dba)3/triethylphosphite to generate the corresponding N-protected peptidyl ketones in good-to-excellent yields and in high enantiopurity. Triethylphosphite plays a key role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation−β-elimination of the α-amino thiol esters. The peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality.
65 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 2 |
| 2020 | 4 |
| 2019 | 2 |
| 2018 | 5 |
| 2017 | 6 |