Topic
Trauma trigger
About: Trauma trigger is a research topic. Over the lifetime, 7 publications have been published within this topic receiving 105 citations. The topic is also known as: trauma stimulus & trauma stressor.
Papers
TL;DR: Inflammasomes are involved in the innate responses to traumatic brain injury and contribute to the development of acute respiratory distress syndrome and may also play a role in post-trauma immunosuppression mediated by dysregulated monocyte functions.
Abstract: Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to vital organs are responsible for early mortality whereas most delayed deaths are secondary to complex pathophysiological processes. These processes result from imbalanced systemic reactions to the multiple aggressions associated with trauma. Trauma results in the uncontrolled local and systemic release of endogenous mediators acting as danger signals [damage-associated molecular patterns (DAMPs)]. Their recognition by the innate immune system triggers a pro-inflammatory immune response paradoxically associated with concomitant immunosuppression. These responses, ranging in intensity from inappropriate to overwhelming, promote the propagation of injuries to remote organs, leading to multiple organ failure and death. Some of the numerous DAMPs released after trauma trigger the assembly of intracellular multiprotein complexes named inflammasomes. Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. Following trauma-induced DAMP(s) recognition, inflammasomes participate in multiple ways in the development of exaggerated systemic and organ-specific inflammatory response, contributing to organ damage. Inflammasomes are involved in the innate responses to traumatic brain injury and contribute to the development of acute respiratory distress syndrome. Inflammasomes may also play a role in post-trauma immunosuppression mediated by dysregulated monocyte functions. Characterizing the involvement of inflammasomes in the pathogenesis of post-trauma syndrome is a key issue as they may be potential therapeutic targets. This review summarizes the current knowledge on the roles of inflammasomes in trauma.
233 citations
TL;DR: The authors examines commonplaces in the debate over using trigger warnings in college classes with special attention given to the repudiation of "sensitivity" arguments against sensitivity and concludes that "arguments against sensitivity have...
Abstract: This article examines commonplaces in the debate over using trigger warnings in college classes with special attention given to the repudiation of “sensitivity.” Arguments against sensitivity have ...
32 citations
TL;DR: This case study of a 5-month-old infant describes the symptoms of trauma following a surgical procedure (cranial remodeling) with short-term hospital stay, with the disappearance of some symptoms of traumatic stress disorder after the first week, and no remaining symptoms after two months.
Abstract: This case study of a 5-month-old infant describes the symptoms of trauma following a surgical procedure (cranial remodeling) with short-term hospital stay. The infant showed a symptomatology similar to that found in other studies of hospitalization during the preverbal period, and fit the diagnosis of traumatic stress disorder according to the DC:0-3. The therapy was implemented by the parents in consultation with the author. The approach was based on an exposure therapy model (flooding) using a somatic trauma trigger that occurred spontaneously in the context of a normal caretaking routine. The infant was allowed to have a full-blown emotional response during several treatment sessions. The outcome was positive, with the disappearance of some symptoms of traumatic stress disorder after the first week, and no remaining symptoms after two months. Periodic follow-up evaluations for one year revealed normal development with no return of symptoms. The symptoms, treatment, and outcomes are discussed in the context of behavioral learning theory and emotional processing theory. The role of crying during flooding therapy is discussed, and an emotional release theory emphasizing the therapeutic value of crying is proposed. Six cautionary guidelines are offered for the use of intense exposure therapy with infants.
10 citations
TL;DR: In this paper, the potential role of physical and psychological trauma in the development of multiple sclerosis has been discussed and the evidence for and against a relationship has been presented for both positive and negative relationships.
Abstract: The potential role of trauma in the development of multiple sclerosis is important but controversial. Patients commonly ask about this and it has important medicolegal ramifications. In addressing such issues this article will consider both physical and psychological trauma, examine pathogenic mechanisms, and discuss the evidence for and against a relationship.
7 citations
1 Jan 2003
TL;DR: The potential role of trauma in the development of multiple sclerosis is important but controversial, both physical and psychological trauma is considered, and the evidence for and against a relationship is discussed.
4 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2018 | 2 |
| 2007 | 1 |
| 2003 | 2 |
| 1976 | 1 |