Topic
Transitive RNA interference
About: Transitive RNA interference is a research topic. Over the lifetime, 8 publications have been published within this topic receiving 323 citations.
Papers
TL;DR: Evidence that dsRNA is amplified in Caenorhabditis elegans to ensure a robust RNAi response is provided, and data suggest ds RNA synthesized in vivo can mediate systemic RNAi.
Abstract: When a cell is exposed to double-stranded RNA (dsRNA), mRNA from the homologous gene is selectively degraded by a process called RNA interference (RNAi). Here, we provide evidence that dsRNA is amplified in Caenorhabditis elegans to ensure a robust RNAi response. Our data suggest a model in which mRNA targeted by RNAi functions as a template for 5' to 3' synthesis of new dsRNA (termed transitive RNAi). Strikingly, the effect is nonautonomous: dsRNA targeted to a gene expressed in one cell type can lead to transitive RNAi-mediated silencing of a second gene expressed in a distinct cell type. These data suggest dsRNA synthesized in vivo can mediate systemic RNAi.
133 citations
TL;DR: Effective transitive RNAi is demonstrated in the ascomycete Aspergillus oryzae and real-time RT-qPCR analysis demonstrated a direct correspondence of steady-state wA mRNA level to spore color.
20 citations
Patent•
20 Dec 2007TL;DR: In this article, a method for reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference was proposed. But this method is not suitable for the case of a single gene.
Abstract: The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference.
8 citations
Patent•
20 Dec 2007TL;DR: In this article, a method for reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference was proposed. But this method is not suitable for the case of a single gene.
Abstract: The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference.
3 citations
Patent•
16 Aug 2013TL;DR: In this article, a method for co-silencing expression of genes in a filamentous fungal strain by transitive RNA interference was proposed, and the method also relates to identifying a gene encoding a biological substance of interest.
Abstract: The present invention relates to methods for co-silencing expression of genes in a filamentous fungal strain by transitive RNA interference. The present invention also relates to methods for identifying a gene encoding a biological substance of interest.
2 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2013 | 2 |
| 2012 | 1 |
| 2007 | 3 |
| 2003 | 2 |