Topic
Tonofibril
About: Tonofibril is a research topic. Over the lifetime, 34 publications have been published within this topic receiving 1973 citations. The topic is also known as: tonofilament.
Papers
TL;DR: In this paper, epithelial tissues function to protect the organism from physical, chemical, and microbial damage and are essential for survival and to perform this role, epithelial keratinocytes undergo a well-defin...
Abstract: Epithelial tissues function to protect the organism from physical, chemical, and microbial damage and are essential for survival. To perform this role, epithelial keratinocytes undergo a well-defin...
403 citations
TL;DR: Desmosomes and hemidesmosomes are extremely different in their molecular composition, but show specialization for plaque formation and intermediate filament attachment and may turn out to be involved in signal transduction.
322 citations
TL;DR: It is proposed that membrane templating, rather than spontaneous self-assembly, is responsible for keratin intermediate filament formation and dynamics.
170 citations
TL;DR: Having determined the specificity of the antisera by immunoblotting, it is shown that each gives a staining pattern corresponding to the distribution of desmosomes in a range of tissues from different vertebrate species, demonstrating that desmosomal components are widely shared and highly conserved.
Abstract: Many workers regard cell adhesion as a highly specific phenomenon, believing that different molecular mechanisms are involved in the adhesion of cells of different tissues and different species. We believe that the evidence from cell behaviour is against this view and that cells share common adhesion mechanisms (for reviews see refs 1, 2); however, molecular evidence is lacking. As an approach to providing such evidence we have begun to study desmosomes, the cell-surface organelles responsible for strong intercellular adhesion in epithelia. We have raised antisera against each of five high-molecular weight (MW) desmosomal components. Having determined the specificity of our antisera by immunoblotting, we show here that each gives a staining pattern corresponding to the distribution of desmosomes in a range of tissues from different vertebrate species, demonstrating that desmosomal components are widely shared and highly conserved.
163 citations
TL;DR: Hemidesmosomes are organized around a core of actin filaments that appears early during cell adhesion, and podosome-like structures look similar to podosomes described in cells of mesenchymal origin.
118 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2016 | 2 |
| 2015 | 1 |
| 2013 | 1 |
| 2011 | 1 |
| 2009 | 2 |
| 2005 | 1 |