Topic
Thyroxine analog
About: Thyroxine analog is a research topic. Over the lifetime, 14 publications have been published within this topic receiving 262 citations.
Papers
TL;DR: This study provides the first evidence for an anatomical basis, i.e., attenuated ventricular remodeling and arteriolar growth, for improved function attributed to DITPA therapy of the infarcted heart.
Abstract: Myocardial infarction (MI) is characterized by ventricular remodeling, hypertrophy of the surviving myocardium, and an insufficient angiogenic response. Thyroxine is a powerful stimulus for myocard...
67 citations
TL;DR: Values for free T4 obtained with these kits correlate well with values obtained with other radioimmunoassay kits developed for measuring the serum free thyroxine (T4) concentration.
Abstract: Excerpt Various radioimmunoassay kits have been developed for measuring the serum free thyroxine (T4) concentration. Values for free T4 obtained with these kits correlate well with values obtained ...
55 citations
TL;DR: A magnetic particles-based chemiluminescence enzyme immunoassay with high sensitivity, specificity, rapidity, and reproducibility was developed and has been successfully applied to the analysis of free thyroxine in human serum.
40 citations
TL;DR: A library of 16 thyroxine analog biosensors were prepared for use on the BIAcore surface plasmon resonance instrument and an anti-thyroxine monoclonal antibody and its Fab fragment were tested with each biosensor to generate the association and dissociation rate constants, equilibrium association constants, and Gibbs free energy values for characterizing the binding event.
22 citations
TL;DR: It is concluded that DIMIT crosses the rabbit placenta and stimulates lecithin synthesis and PAPase activity in fetal lung and these two hormones may act in part by controlling the same enzyme.
Abstract: To investigate the possible role of thyroid hormones in fetal lung maturation, we treated pregnant rabbits with 3,5-dimethyl-3′-isopropylthyronine (DIMIT), a thyroxine analog which binds to nuclear receptors in fetal lung. On days 24 and 25 of gestation does received diluent or 0.05-1 mg/kg DIMIT im; fetuses were studied on day 26. We found no effect of DIMIT on viability, body weight, lung weight, lung wet/dry ratio, or fetal plasma cortisol levels. NADPH-cytochrome C reductase, a known T4 inducible enzyme, was increased 64% (p<0.01) in fetal liver with 1 mg/kg DIMIT. Mean±SE values for the rate of 3H-choline incorporation into lecithin (pmol/mg tissue/h) by minced fetal lung and activity of phosphatidic acid phosphatase (PAPase, nmol/mg prot/min) in lung homogenate are shown below (*=p<0.001): Similar results were found for incorporation of 3H-glycerol. We conclude that DIMIT crosses the rabbit placenta and stimulates lecithin synthesis and PAPase activity in fetal lung. Since similar effects occur with glucocorticoid treatment, these two hormones may act in part by controlling the same enzyme.
13 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2009 | 1 |
| 2007 | 1 |
| 2004 | 1 |
| 1998 | 1 |
| 1997 | 1 |
| 1984 | 1 |