Topic
Third ventricle
About: Third ventricle is a research topic. Over the lifetime, 2401 publications have been published within this topic receiving 45960 citations.
Papers published on a yearly basis
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Papers
TL;DR: Many elderly subjects did not exhibit cortical atrophy or lateral ventricular enlargement, however, indicating that such changes are not inevitable consequences of advancing age, and these data should provide a useful clinical context within which to interpret changes in regional brain size associated with “abnormal” aging.
Abstract: Seventy-six healthy adults underwent magnetic resonance imaging (1.5 T) to investigate the effects of age on regional cerebral volumes and on the frequency and severity of cortical atrophy, lateral ventricular enlargement, and subcortical hyperintensity. Increasing age was associated with (1) decreasing volumes of the cerebral hemispheres (0.23% per year), the frontal lobes (0.55% per year), the temporal lobes (0.28% per year), and the amygdalahippocampal complex (0.30% per year); (2) increasing volumes of the third ventricle (2.8% per year) and the lateral ventricles (3.2% per year); and (3) increasing odds of cortical atrophy (8.9% per year), lateral ventricular enlargement (7.7% per year), and subcortical hyperintensity in the deep white matter (6.3% per year) and the pons (8.1% per year). Many elderly subjects did not exhibit cortical atrophy or lateral ventricular enlargement, however, indicating that such changes are not inevitable consequences of advancing age. These data should provide a useful clinical context within which to interpret changes in regional brain size associated with “abnormal” aging.
541 citations
TL;DR: The authors used quantitative X-ray computed tomography to analyze the brain volume of 10 male patients with severe primary obsessive-compulsive disorder and 10 healthy male control subjects to support other evidence of involvement of the caudate nucleus in obsessive- compulsive disorder.
Abstract: New brain imaging techniques may provide evidence for a biological basis for severe psychiatric disorders The authors used quantitative X-ray computed tomography (CT) to analyze the brain volume of 10 male patients with severe primary obsessive-compulsive disorder and 10 healthy male control subjects Caudate nucleus volume in the patients with obsessive-compulsive disorder was significantly less than that of control subjects, but lenticular nuclei, third ventricle, and lateral ventricle volumes did not differ between these two groups, and no abnormal asymmetry of bilateral structures was detected These findings support other evidence of involvement of the caudate nucleus in obsessive-compulsive disorder
295 citations
TL;DR: There was a statistically significant increase of all cerebral parameters with age, and the cella media index showed a correspondingly small decrease with age.
Abstract: The brains of 100 normal adults were examined with 160×160 matrix computed tomography (CT) The left lateral ventricle was found to be larger than the right in both sexes, and both lateral ventricles were larger in the male There was a statistically significant increase of all cerebral parameters with age, and the cella media index showed a correspondingly small decrease with age The linear measurements of the lateral ventricles demonstrated positive correlation to cranial size, while the widths of the third ventricle and of the hemispheric sulci were independent of the size of the skull
286 citations
TL;DR: A cilia-based transport network that suggests how cerebrospinal fluid constituents are actively distributed is revealed in the brain is revealed and suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks.
Abstract: Cerebrospinal fluid conveys many physiologically important signaling factors through the ventricular cavities of the brain. We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle. We also discovered a cilia-based switch that reliably and periodically alters the flow pattern so as to create a dynamic subdivision that may control substance distribution in the third ventricle. Complex flow patterns were also present in the third ventricles of rats and pigs. Our work suggests that ciliated epithelia can generate and maintain complex, spatiotemporally regulated flow networks.
283 citations
269 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 30 |
| 2024 | 40 |
| 2023 | 102 |
| 2022 | 149 |
| 2021 | 63 |
| 2020 | 77 |