Topic
Thioproperazine
About: Thioproperazine is a research topic. Over the lifetime, 85 publications have been published within this topic receiving 1281 citations. The topic is also known as: N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide & N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide.
Papers published on a yearly basis
Papers
TL;DR: The effects of 6 benzamides and 8 classical neuroleptics were studied on 6 different apomorphine-induced effects and the differences are discussed according to the two types of dopaminergic receptor hypothesis.
91 citations
TL;DR: Biosynthesis of 3H-CA in discrete areas of the rat brain was examined after stereotaxic microinjection of3H-tyrosine and the effects of amphetamine and thioproperazine (TZ) on the accumulation of newly synthesized 2H-DA and 3H -NA were studied.
78 citations
TL;DR: Thioproperazine pretreatment potentiated amphetamine induced release of 3 H-DA but it blocked the other pharmacological effects of amphetamine occurring in animals.
70 citations
TL;DR: An automated flow injection determination of some phenothiazine derivatives, based on their oxidation with iron(III) in a strongly acidic medium, is described, with precision better than 1% and a measurement rate of 120 per hour can be obtained.
Abstract: An automated flow injection determination of some phenothiazine derivatives, based on their oxidation with iron(III) in a strongly acidic medium, is described. Chlorpromazine, promethazine, thioproperazine, promazine, levomepromazine, fluphenazine, trifluoperazine and thioridazine are determined in the range 10–250 µg ml–1. The precision is better than 1% and a measurement rate of 120 per hour can be obtained. The method was evaluated by carrying out an interference study with common excipients and other drugs, a recovery study and by the analysis of commercial formulations, the results of which are compared with those obtained by the official method. The method was applied in content uniformity tests and for monitoring the dissolution of solid dosage forms.
51 citations
TL;DR: Repeated treatment with reserpine increased tyrosine hydroxylase activity in the brain stem and the cortex; in contrast, repeated treatment with thioproperazine decreased the enzyme activity in these two structures.
44 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2011 | 2 |
| 2001 | 1 |
| 1998 | 1 |
| 1997 | 1 |
| 1994 | 1 |
| 1989 | 2 |