Thiocarlide

TL;DR: Antimycobacterial drugs such as isoniazid; ethionamide and thiocarlide are inhibitors of mycolic acid synthesis in Mycobacterium tuberculosis that appears to block the formation of a Δ 5 −C 24:1 fatty acid which could be a precursor of my colic acids.

TL;DR: The drug appears to have had an effect on the disease in at least four of the 16 patients, with a clear indication of the ‘fall and rise’ phenomenon, with decrease of bacterial content of the sputum followed by an increase.

TL;DR: Results obtained indicate the thiocarlide is well absorbed, reaching maximum blood levels 1/2–2 hours following ingestion, and that it was either being excreted in the form of an inactive metabolite or that the main pathway of excretion was via the biliary tract.