Topic
Thioamide
About: Thioamide is a research topic. Over the lifetime, 1517 publications have been published within this topic receiving 20582 citations. The topic is also known as: thioamides & thionamide.
Papers published on a yearly basis
1 / 2
Papers
Patent•
8 Dec 1989
TL;DR: The rate of absorption of drugs across skin and other body membranes such as mucous membranes and the blood brain barrier is enhanced by adding to the drug composition a compound which enhances the rate as mentioned in this paper.
Abstract: The rate of absorption of drugs across skin and other body membranes such as mucous membranes and the blood brain barrier is enhanced by adding to the drug composition a compound which enhances the rate. This compound may be macrocyclic ester, diester, amide, diamide, amidine, diamidine, thioester, dithioester, thioamide, ketone or lactone. The macrocyclic ketone contains at least 12 carbon atoms.
469 citations
TL;DR: In this article, the thiation properties of the dimer of p-methoxyphenylthionophosphine sulfide were investigated by performing reactions with a representative series of aliphatic and aromatic primary, secondary, and tertiary carboxamides in the temperature range 80-100 °C using HMPA as solvent.
Abstract: The thiation properties of the dimer of p-methoxyphenylthionophosphine sulfide, 1, has been investigated by performing reactions with a representative series of aliphatic and aromatic primary, secondary, and tertiary carboxamides in the temperature range 80-100 °C using HMPA as solvent. This new method seems to be superior to all others as in most cases quantitative yields are found. Salicylanilide, when reacted with 1, in HMPA, yields salicylthioanilide and a new type of phosphorus heterocycle, 3, whose structure has been determined by NMR-and X-ray analyses. 13C NMR data are tabulated for a series of thioamide carbons.
344 citations
TL;DR: In this article, a modified Hantzsch reaction was investigated and conditions were found to reach enantiomerically pure thiazole amino acid derivatives, which is the same as the conditions used in this paper.
137 citations
TL;DR: X-ray crystallography of peptides: The contributions of the Italian laboratories TLDR - A review summarizing solid-state structural and conformational results obtained in Italian laboratories in studies of synthetic and natural peptides by x-ray diffraction analyses.
Abstract: The review article summarizes the most relevant solid state structural and conformational results obtained in the laboratories involved in Italy in the studies of synthetic and natural peptides by x-ray diffraction analyses. Some of the topics will include research studies carried out in other European countries, whereas in other cases studies carried out in Italy will be included in other review articles included in this volume. The review deals with peptides containing symmetrically achiral and unsymmetrically chiral C alpha,alpha-dialkylated glycine residues, peptides containing beta-alanine residues, alpha,beta-dehydroamino acid residues, and aminosuccinyl residues, peptides containing the thioamide surrogate, heterochiral peptides and several bioactive peptides systems with the proposed relationships between function and structure.
131 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 20 |
| 2024 | 28 |
| 2023 | 38 |
| 2022 | 77 |
| 2021 | 31 |
| 2020 | 46 |