Topic
Thin layer extraction
About: Thin layer extraction is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 19 citations.
Papers
TL;DR: The Thin Layer Extraction (TLX) method as mentioned in this paper is a novel method to carry out liquid-liquid extraction using specialized equipment and temporal modes of operation, which can be easily scaled up to production floor size or down to the microscale.
Abstract: The overall task of a liquid–liquid extraction process consists of selectively transferring solutes from a donor solution to a recipient solution through a liquid extractant, with the purpose of purifying the donor solution and/or recovering a valuable solute. Thin layer extraction (TLX) is a novel method to carry out this task, using specialized equipment and temporal modes of operation. In TLX, a minute amount of an extractant that is firmly attached as thin layer to a solid substrate is intimately and frequently brought into contact alternately with the donor and recipient solutions. TLX incorporates the complete extraction/stripping scheme into one single device. Following presentation of the underlying concepts, the structural, design, and operational aspects are discussed. TLX is applicable on a wide range of scales and can be easily scaled up to production floor size or down to the microscale. It has inherent operational, safety, and environmental qualities. © 2008 American Institute of Chemical Engineers AIChE J, 2008
13 citations
Journal Article•
TL;DR: In this article, a theoretical study of kinetic chiral resolution of ionic compounds by thin layer extraction, based on a model that has been successfully tested experimentally by others, indicates that considerable resolution may be achieved in a single contacting stage provided the reaction rates of the two enantiomers are sufficiently differentiated.
Abstract: A theoretical study of kinetic chiral resolution of ionic compounds by thin layer extraction, based on a model that has been successfully tested experimentally by others indicates that considerable resolution may be achieved in a single contacting stage provided the reaction rates of the two enantiomers are sufficiently differentiated. The role played by various design and operation parameters is delineated.
2 citations
TL;DR: Kinetic reactive thin layer extraction (KRTLX) offers an alternative route that does not rely on finding such a particularly selective host, provided the rates of the chemical reactions between each of the two components and the host are sufficiently differentiated as discussed by the authors.
Abstract: When the separation of two closely related compounds by liquid–liquid extraction is necessary, conventional wisdom indicates that a selective extractant must be found that will discern between the two by associating with each to different equilibrium compositions. Kinetic reactive thin layer extraction (KRTLX) offers an alternative route that does not rely on finding such a particularly selective host, provided the rates of the chemical reactions between each of the two components and the host are sufficiently differentiated. The optimal design of a KRTLX application requires kinetic data pertaining to the reactions between the components to be separated and the active host in the extractant. The actual implementation of a KRTLX application requires the availability of extraction equipment that allows control of the time span of the reactions, such as is availed by the TLX extractor. KRTLX is modeled and explored numerically on the basis of published kinetic data. A calculated example, concerning the sepa...
1 citations
Journal Article•
TL;DR: The Thin Layer Extraction (TLE) method as mentioned in this paper is a relatively new, versatile version of liquid-liquid extraction that offers a simple and economical solution to chiral resolution.
Abstract: Enantiomers play an important role in the pharma, flavors and fragrances, agrochemicals and food industries. They are presently obtained by one of several methods, including asymmetric synthesis, crystallization and chromatography. Impediments in the present methods such as low versatility, high cost and limited economical production volumes have attracted in recent years interest in chiral resolution by liquid-liquid extraction. However, conventional liquid-liquid extraction is also impeded by bulky and/or costly equipment and by the high cost of the chiral hosts used in the extractant. Thin Layer Extraction, a relatively new, versatile version of liquid-liquid extraction promises a simple and economical solution.
1 citations
TL;DR: In this paper, the role played by various parameters when applying thin layer extraction to the resolution of an ionic racemic mixture into its enantiomer components is analyzed, and the analysis provides a critical insight that facilitates the design of a successful separation scheme.
Abstract: The increasing demand for enantiomer intermediates has attracted in recent years attention to liquid–liquid extraction as a scalable chiral resolution method. Thin layer extraction, a simple and effective form of liquid–liquid extraction that uses little extractant, promises economic utilization of the most selective chiral hosts. The role played by various parameters when applying thin layer extraction to the resolution of an ionic racemic mixture into its enantiomer components is analyzed. This analysis provides a critical insight that facilitates the design of a successful separation scheme. It transpires that, given a suitable host, certain conditions concerning the host concentration and the pH and rate of the feed and strip solutions must be balanced to obtain optimum enantioseparation or even to obtain any separation at all. A calculated example that is based on experimental data from the published literature indicates that a simple thin layer extractor, using a crown ether host, is capable of sepa...
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2014 | 1 |
| 2013 | 1 |
| 2011 | 2 |
| 2008 | 1 |