Topic
Tetrazepam
About: Tetrazepam is a research topic. Over the lifetime, 88 publications have been published within this topic receiving 1177 citations.
Papers published on a yearly basis
Papers
TL;DR: The present study demonstrates that this metabolic conversion of tetrazepam can also be predicted on the basis of a purely instrumental method, consisting of an electrochemical cell coupled to online liquid chromatography (LC) and mass spectrometry (MS).
84 citations
TL;DR: A gas chromatographic method combined with mass spectrometric detection was developed, optimized and validated for the determination of the above substances and was successfully applied for the investigation of both forensic and clinical toxicological cases of accidental and suicidal poisoning.
71 citations
TL;DR: The solubilty and stability of the chemically unstable drug tetrazepam which has poor water solubility have been studied in bile salts-phosphatidylcholine-mixed micelles (BS-PC-MM) and indicated first order degradation kinetics in most cases under aerobic conditions.
59 citations
Journal Article•
TL;DR: A withdrawal syndrome marked by myalgia, and cold feeling was transient, and alleviated by sedative phenothiazine (cyamemazine) and myorelaxant benzodiazepine (tetrazepam).
Abstract: The authors report a case of tianeptine abuse in a 30 year-old woman. After a medical prescription of the recommended dosage of 12.5 mg 3 times daily of oral tianeptine for a depressive illness, the patient spontaneously increased the dosage which after two months reached 150 tablets per day. No severe toxic effects were observed. As adverse effects, the patient, in the beginning of this high treatment period suffered from nausea, vomiting, abdominal pain, anorexia with weight loss, constipation. These side effects progressively disappeared. The biological tolerance was excellent, and hepatic parameters were not affected. The patient experienced and seek a psychostimulant effect. After seven months of such a therapy, she was hospitalized to undergo a withdrawal. The discontinuation of the tianeptine treatment occurs in four days. A withdrawal syndrome marked by myalgia, and cold feeling was transient, and alleviated by sedative phenothiazine (cyamemazine) and myorelaxant benzodiazepine (tetrazepam).
40 citations
1 Jan 1992
39 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2019 | 2 |
| 2017 | 1 |
| 2016 | 3 |
| 2015 | 1 |
| 2014 | 3 |