Topic
TAF9
About: TAF9 is a research topic. Over the lifetime, 391 publications have been published within this topic receiving 18757 citations. The topic is also known as: MGC:5067 & STAF31/32.
Papers published on a yearly basis
Papers
TL;DR: The evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II.
Abstract: Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. Current data indicate that pausing is particularly enriched at genes in signal-responsive pathways. Here the evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II.
1,233 citations
TL;DR: It is shown that expression of a human equivalent to Drosophila's C4 pol II in human cultured cells affects alternative splicing of the fibronectin EDI exon and adenovirus E1a pre-mRNA and resplices of the Hox gene Ultrabithorax are stimulated, which demonstrates the transcriptional control ofAlternative splicing on an endogenous gene.
760 citations
TL;DR: It is shown that polymeric fibers formed from these LC domains directly bind the C-terminal domain (CTD) of RNA polymerase II in a manner reversible by phosphorylation of the iterated, heptad repeats of the CTD.
556 citations
TL;DR: The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf, which can encode a WD repeat protein.
515 citations
TL;DR: The aim of this work is to provide the basic facts about TDP-43 an assessment of the multiple functions ascribed to this protein and to suggest that it may be involved in other cellular processes such as microRNA biogenesis, apoptosis, and cell division.
Abstract: TDP-43 is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member and displays a significant specificity for binding the common microsatellite region (GU/GT)n. Initially described as a regulator of HIV-1 gene expression, it has been reported in the past to affect both normal and pathological RNA splicing events. In particular, it has been shown to play a fundamental role in the occurrence of several monosymptomatic/full forms of Cystic Fibrosis caused by pathological skipping of CFTR exon 9 from the mature mRNA. Recently, and in a way probably unrelated to splicing, a hyperphosphorylated form of TDP-43 has also been found to accumulate in the cytoplasm of neuronal cells of patients affected by fronto temporal lobar degenerations. In addition to its role in transcription and splicing regulation, a growing body of evidence indirectly suggests that TDP-43 may be involved in other cellular processes such as microRNA biogenesis, apoptosis, and cell division. The aim of this work is to provide the basic facts about TDP-43 an assessment of the multiple functions ascribed to this protein.
508 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2017 | 3 |
| 2016 | 4 |
| 2015 | 6 |
| 2014 | 12 |
| 2013 | 8 |
| 2012 | 11 |