Topic
TAF2
About: TAF2 is a research topic. Over the lifetime, 2160 publications have been published within this topic receiving 141529 citations. The topic is also known as: CIF150 & MRT40.
Papers published on a yearly basis
Papers
TL;DR: The transcription factor XBP1, a target of ATF6, is identified as a mammalian substrate of such an unconventional mRNA splicing system and it is shown that only the spliced form of X BP1 can activate the UPR efficiently.
4,107 citations
TL;DR: It is shown that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human E-CADherin promoter and represses transcription of E- cadhersin.
Abstract: The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of E-cadherin gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human E-cadherin promoter and represses transcription of E-cadherin. Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the E-cadherin gene.
2,790 citations
TL;DR: The biological and molecular functions of the NAC family are summarized, paying particular attention to the intricate regulation of NAC protein level and localization, and to the first indications of Nac participation in transcription factor networks.
1,448 citations
TL;DR: Sterol-regulated proteolysis of a membrane-bound transcription factor provides a novel mechanism by which transcription can be regulated by membrane lipids.
1,053 citations
TL;DR: Experiments reveal crosstalk between histone modifications and the transcription factor TFIID, which has important implications for regulation of RNA polymerase II-mediated transcription in higher eukaryotes.
949 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 3 |
| 2023 | 8 |
| 2022 | 3 |
| 2021 | 4 |
| 2019 | 1 |
| 2018 | 7 |