Syphilid

Abstract: arterioveneuses multiples. Bull Soc Fr Derm Syph 1967; 74: 664 ^ 665. 5. KÎnig A, BrÏngger A, Schnyder UW. Kaposiform acro-angiodermatitis with arteriovenous malformation (Stewart-Blufarb syndrome). Dermatologica 1990; 181: 254 ^ 257. 6. Ashida ER, Johnson AR, Lipsky PE. Human endothelial cell lymphocyte interaction. J Clin Invest 1981; 67: 1490 ^ 1499. 7. Auerbach R, Sidky YA. Nature of the stimulus leading to a lymphocyte induced angiogenesis. J Immunol 1979; 123: 751 ^ 754. 8. Ziche M, Jones J, Gullino PM. Role of prostagrandin E1 and copper in angiogenesis. J Natl Canc Inst 1982; 69: 475 ^ 482.

Abstract: From time to time and under a variety of terms there has been discussed in the literature and at meetings of most of the American dermatologic societies a rare ulcerative cutaneous lesion, the specificity of which in relation to one or more of the usual pyogenic organisms is as yet not settled. Nevertheless, it has for many years been tentatively classified with ulcerative pyodermas. Ulcers of this kind have several clearcut clinical characteristics which I think distinguish them from certain other conditions. They have a tendency to persist and progress and to have undermining borders which develop as they progress and a tendency to recur after apparent cure, either in the same or in another locality. In a general way they are syphiloid, so much so that many of the patients are given long courses of antisyphilitic medication before the observer concludes that the condition is a resistant syphilid or

Abstract: Syphilis, a sexually transmitted disease caused by Treponema pallidum, manifests with a broad spectrum of clinical presentations that usually involves skin. Nodular secondary syphilis occurs rarely, and mostly manifests as disseminated papulonodules or plaques over the trunk and limbs. We report an extremely rare case of nodular secondary syphilis that primarily presented with multiple nodules on the scalp, resembling Rosai-Dorfman disease or cutaneous malignant metastasis. Immunohistochemistry confirmed T. pallidum spirochetes microscopically.

Abstract: Background: Syphilis is infectious and chronic disease transmitted sexually and caused by Treponema pallidum subspecies pallidum. Thanks to the wide-ranging variance in clinical presentations, the disease has earned the name, “the Great Mimicker”. The prevalence rate of syphilis in Korea dropped sharply since the 1970s and has remained low until recently when the rate started to show signs of a modest but clear increase. Objective: The objective of this study is to evaluate the incidence of syphilis and describe its clinical characteristics of each stage as we have observed for the past 8 years at our hospital. Methods: We conducted a retrospective analysis on the 279 syphilis patients who visited our hospital from 2000 to 2007. For the diagnosis of the disease, we used nontreponemal (VDRL) and treponemal test (TPHA, FTA-ABS) in serum and evaluated the clinical features of the subjects. Results: The annual incidence and prevalence rate of early syphilis showed a statistically significant upward trend. By gender, the annual incidence rate among males also drew an upward curve. Among 279 patients, 28 cases of early syphilis were found in males, whereas only 16 cases were found in females. Early syphilis is found most frequently in the twenties. Secondary syphilis showed various skin lesions including alopecia syphlitica, macular syphilid, papulosquamous syphlid and annular patch. Nine cases among 19 syphilis patients showed coppery red macules on palms and soles. One case of early latent syphilis was found in a HIV-positive patient. The serum VDRL titers according to stages did not show a statistically significant difference. Conclusion: We have observed statistically significant (p＜0.05) increase in the incidence and prevalence rates of early syphilis in recent years. Thus, dermatologists should be rightly aware of and familiarize themselves with the diverse clinical features of syphilis and be attentive and alert to effectively diagnose the disease in its early stages. (Korean J Dermatol 2008;46(10):1344∼1352)