TL;DR: It is shown that microscopically only a small part of the spinal gray matter falls into well delimited cytoarchitectonic regions such as the substantia gelatinosa Rolandi or belongs to nuclei such as Clarke’s column, the motor muscle nuclei, etc.
Abstract: Nervous centers, such as the cerebral cortex, the lateral geniculate body, the thalamus, etc., can generally be described as being built up of a number of cell layers, regions or nuclei, which are adequately characterized by the shape, arrangement and connections of their constituent cells. It is a notable fact, however, that the current descriptions of the spinal cord gray matter use its macroscopical features as the dominant principle of structural organization. Thus we have a dorsal and a ventral horn or cell column, the former has a head, a neck and a base, etc. None of these regions can be defined by cytological or cytoarchitectonic characteristics, nor is it possible to fit them into a larger cytoarchitectonic region. Microscopically only a small part of the spinal gray matter falls into well delimited cytoarchitectonic regions such as the substantia gelatinosa Rolandi or belongs to nuclei such as Clarke’s column, the motor muscle nuclei, etc. The rest of the cells are either left in macroscopically characterized regions as already noted or loosely referred to as, e.g., cells of the zona intermedia, where again no description of extent or character of the region can be given. In other regions some cells are more or less subjectively picked out from among a great number, as is the case with, for instance certain authors’ solitary
TL;DR: In mice lacking Lbx1, cells types that arise in the ventral alar plate acquire more dorsal identities, which results in the loss of dorsal horn association interneurons, excess production of commissural neurons, and disrupted sensory afferent innervation of the dorsal horn.
TL;DR: A single progenitor homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord.
TL;DR: It is shown that Evx1 V0 interneurons are locally projecting intersegmental commissural neurons and misexpression of Evx2 represses En1, suggesting that EvX1 may suppress the V1 interneuron differentiation program.
TL;DR: It is found that locomotor pattern degrades upon elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs, establishing a role for proprioception feedback in the control of fundamental aspects of mammalian locomotor behavior.
Abstract: Mammalian locomotor programs are thought to be directed by the actions of spinal interneuron circuits collectively referred to as "central pattern generators" The contribution of proprioceptive sensory feedback to the coordination of locomotor activity remains less clear We have analyzed changes in mouse locomotor pattern under conditions in which proprioceptive feedback is attenuated genetically and biomechanically We find that locomotor pattern degrades upon elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs The degradation of locomotor pattern is manifest as the loss of interjoint coordination and alternation of flexor and extensor muscles Group Ia/II sensory feedback from muscle spindles has a predominant influence in patterning the activity of flexor muscles, whereas the redundant activities of group Ia/II and group Ib afferents appear to determine the pattern of extensor muscle firing These findings establish a role for proprioceptive feedback in the control of fundamental aspects of mammalian locomotor behavior