TL;DR: Pulse wave analysis has been an important part of the medical examination from ancient times as discussed by the authors, and it has been used to detect asymptomatic hypertension and to chart the natural history of essential hypertension and distinguish between this condition and chronic nephritis.
Abstract: PULSE WAVE ANALYSIS IN HISTORICAL TIMES: Interpretation of the arterial pulse has been an important part of the medical examination from ancient times. Graphic methods for clinical pulse wave recording were introduced by Marey in Paris and by Mahomed in London last century. Mahomed showed how such recordings could be used to detect asymptomatic hypertension, and used them to chart the natural history of essential hypertension and to distinguish between this condition and chronic nephritis. Interest in arterial pulse analysis, as applied by Mahomed, lapsed with the introduction of the cuff sphygmomanometer 100 years ago. MODERN PULSE WAVE ANALYSIS: Analysis of the arterial pulse is now regaining favour as limitations of the cuff sphygmomanometer are better recognized (including the ability only to measure extremes of the pulse in the brachial artery). In addition, high-fidelity tonometers have been introduced for very accurate, non-invasive measurement of arterial pulse contour, and there is now a better understanding of arterial hemodynamics, and appreciation of disease and aging effects in humans. It is now possible to record the pulse wave accurately in the radial or carotid artery, to synthesize the ascending aortic pulse waveform, to identify systolic and diastolic periods and to generate indices of ventricular-vascular interaction previously only possible with invasive arterial catheterization. Pressure pulse wave analysis now permits more accurate diagnosis and more logical therapy than was ever possible in the past.
TL;DR: Emerging evidence now suggests that central pressure is better related to future cardiovascular events than is brachial pressure, and basing treatment decisions on central pressure, is likely to have important implications for the future diagnosis and management of hypertension.
Abstract: Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular risk. However, systolic pressure varies throughout the arterial tree, such that aortic (central) systolic pressure is actually lower than corresponding brachial values, although this difference is highly variable between individuals. Emerging evidence now suggests that central pressure is better related to future cardiovascular events than is brachial pressure. Moreover, anti-hypertensive drugs can exert differential effects on brachial and central pressure. Therefore, basing treatment decisions on central, rather than brachial pressure, is likely to have important implications for the future diagnosis and management of hypertension. Such a paradigm shift will, however, require further, direct evidence that selectively targeting central pressure, brings added benefit, over and above that already provided by brachial artery pressure.
TL;DR: The paralysis produced by the application of pressure to human limbs both by the sphygmomanometer cuff and by localized pressure on single nerves had centripetal onset and affected touch before pain and pain before motion.
Abstract: Although in clinical neurology peripheral nerve palsies induced by a tourniquet are uncommon, such palsies due to direct pressure of other kinds are frequently met with. Despite this, attempts to define the factors involved in the production of such lesions have been remarkably few. Lewis, Pickering and Rothschild 1 studied the paralysis produced by the application of pressure to human limbs both by the sphygmomanometer cuff and by localized pressure on single nerves. They elicited facts of great interest. The paralysis produced by a cuff had centripetal onset and affected touch before pain and pain before motion. The latency of onset with a cuff around the upper part of the arm was almost constant (paralysis at about the twenty-fifth minute) and was the same with pressures of from 150 to 300 mm. The cuff was without effect at pressures below the systolic blood pressure. When paralysis had commenced, the placement