Topic
SOX14
About: SOX14 is a research topic. Over the lifetime, 30 publications have been published within this topic receiving 2635 citations. The topic is also known as: SOX28 & SRY-box 14.
Papers
TL;DR: A robust phylogeny of SOX genes is proposed that reflects their evolutionary history in metazoans and finds support for subdivision of the family into groups A-H, as has been suggested in some previous studies, and for the assignment of two new groups, I and J.
1,000 citations
TL;DR: It is demonstrated that Sox-3, as well as Sox-1 and Sox-2, are expressed in the urogenital ridge and that their protein products are able to bind the same DNA sequence motif as Sry in vitro, but with different affinities, suggesting an evolutionary link between the genes.
Abstract: The Sox gene family consists of a large number of embryonically expressed genes related via the possession of a 79-amino-acid DNA-binding domain known as the HMG box Partial clones for the first three Sox genes (al-a3) were isolated by homology to the HMG box of the testis-determining gene Sry and are now termed Sox-1, Sox-2 and Sox-3, Sox-3 is highly conserved amongst mammalian species and is located on the X chromosome This has led to the proposal that Sry evolved from Sox-3 We present the cloning and sequencing of Sox-1, Sox-2 and Sox-3 from the mouse and show that Sox-3 is most closely relate to Sry We also confirm that mouse Sox-3 is located on the X chromosome between Hprt and Dmd Analysis of the distribution of Sox-3 RNA shows that its main site of expression is in the developing central nervous system, suggesting a role for Sox-3 in neural development Moreover, we demonstrate that Sox-3, as well as Sox-1 and Sox-2, are expressed in the urogenital ridge and that their protein products are able to bind the same DNA sequence motif as Sry in vitro, but with different affinities These observations prompt discussion of an evolutionary link between the genes and support the model that Sry has evolved from Sox-3 However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties
525 citations
TL;DR: The dynamic and diverse patterns of expression of SOX genes and analysis of mutations suggest that SOX factors play key roles in decisions of cell fate during diverse developmental processes.
521 citations
TL;DR: Activating (B1) and repressing (B2) subgroups of Group B Sox genes display interesting overlaps of expression domains in developing tissues, suggesting that target genes of Group A SOX proteins are finely regulated by the counterbalance of activating and repressed SOXprotein.
332 citations
TL;DR: These results suggest that cooperation of the differential expression of Gli factors and the activity gradient of Shh signaling generates the distinct thalamic neurons at the specific locations in the chick DT.
116 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 2 |
| 2019 | 1 |
| 2017 | 3 |
| 2016 | 1 |
| 2013 | 1 |