Topic
Solid organ
About: Solid organ is a research topic. Over the lifetime, 181 publications have been published within this topic receiving 3937 citations.
Papers published on a yearly basis
Papers
TL;DR: The manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ is highlighted.
Abstract: Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.
895 citations
TL;DR: Findings implicate perivascular Gli1(+) MSC-like cells as a major cellular origin of organ fibrosis and demonstrate that these cells may be a relevant therapeutic target to prevent solid organ dysfunction after injury.
893 citations
TL;DR: Without some form of prevention, CMV infection primarily occurs in the first 3 months following transplant, and onset may be delayed in patients receiving CMV prophylaxis.
345 citations
TL;DR: It is concluded that the expansion of neither population alone inevitably results in graft damage or tolerance in organ transplants.
179 citations
TL;DR: Solid organ transplantations save lives in patients affected by terminal organ failures and improve quality of life, and are increasingly challenged by the growing proportion of elderly transplant patients with comorbidities.
Abstract: Solid organ transplantations save lives in patients affected by terminal organ failures and improve quality of life. Organ transplantations have gradually ameliorated in the last two decades and usually provide excellent results in children and young adults, and are increasingly challenged by the growing proportion of elderly transplant patients with comorbidities. Renal transplantation increases patient survival over dialysis, and lifesaving transplants are indispensible to treat patients with liver, heart, or lung irreversible diseases. Solid organ transplant programs activity has been steadily growing but is still far from global needs, with great differences among countries. Solid organ transplantations are essential for developed and mature health care systems.
131 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 1 |
| 2025 | 170 |
| 2024 | 150 |
| 2023 | 87 |
| 2022 | 142 |
| 2021 | 16 |