Topic
Solanidine
About: Solanidine is a research topic. Over the lifetime, 241 publications have been published within this topic receiving 6344 citations. The topic is also known as: (3beta)-solanid-5-en-3-ol & solanid-5-en-3beta-ol.
Papers published on a yearly basis
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Papers
TL;DR: This review presents an integrated, critical assessment of the multifaceted aspects of the role glycoalkaloids play in nutrition and food safety, and the possible contribution to the multifactorial aspects of teratogenicity is inconclusive.
Abstract: Potatoes, members of the Solanaceae plant family, serve as a major, inexpensive food source for both energy (starch) and good-quality protein, with worldwide production of about 350 million tons per year. U.S. per capita consumption of potatoes is about 61 kg/year. Potatoes also produce potentially toxic glycoalkaloids, both during growth and after harvest. Glycoalkaloids appear to be more toxic to man than to other animals. The toxicity may be due to anticholinesterase activity of the glycoalkaloids on the central nervous system and to disruptions of cell membranes affecting the digestive system and other organs. The possible contribution of glycoalkaloids to the multifactorial aspects of teratogenicity is inconclusive. Possible safe levels are controversial; guidelines limiting glycoalkaloid content of potato cultivars are currently being debated. This review presents an integrated, critical assessment of the multifaceted aspects of the role glycoalkaloids play in nutrition and food safety; che...
443 citations
TL;DR: The described results may make it possible to better relate the structures of the active compounds to their health-promoting function, individually, in combination, and in food, and allow the consumer to select glycoalkaloid-containing food with the optimal content of nontoxic beneficial compounds.
Abstract: Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants, potatoes, and tomatoes. Exposure of cancer cells to glycoalkaloids produced by eggplants (α-solamargine and α-solasonine), potatoes (α-chaconine and α-solanine), and tomatoes (α-tomatine) or their hydrolysis products (mono-, di-, and trisaccharide derivatives and the aglycones solasodine, solanidine, and tomatidine) inhibits the growth of the cells in culture (in vitro) as well as tumor growth in vivo. This overview comprehensively surveys and consolidates worldwide efforts to define the following aspects of these natural compounds: (a) their prevalence in the three foods; (b) their chemistry and structure–activity relationships; (c) the reported factors (biomarkers, signaling pathways) associated with apoptosis of bone, brea...
188 citations
TL;DR: In vitro assays with the recombinant SGT1 isolated from yeast demonstrated that Sgt1 encodes an enzyme capable of both glucosyl transferase and galactosyltransferase activity with a preference for UDP-galactose as the sugar donor, which confirms Sgt1’s role in vivo as the solanidine:UDP-Galactose galacto-transferase.
127 citations
TL;DR: Naturally-occurring 3beta-O-chacotriosides of solasodine, of its 22S, 25S isomer tomatidenol (beta-solamarine), and of solanidine (chaconine) were prepared and assayed in order to assess the relevance of aglycone structural features to membrane-disruption and enzyme-inhibitory activities of the related glycoalkaloids.
106 citations
TL;DR: The data suggest that the glycoalkaloid alpha-chaconine is teratogenic and more embryotoxic than alpha-solanine, in terms of the median lethal concentration after 96 hr of exposure, the concentration inducing gross terata in 50% of the surviving frog embryos, and the minimum concentration needed to inhibit the growth of the embryos.
105 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 7 |
| 2019 | 3 |
| 2018 | 3 |
| 2017 | 4 |
| 2016 | 2 |