Topic
SOAT1
About: SOAT1 is a research topic. Over the lifetime, 82 publications have been published within this topic receiving 6578 citations. The topic is also known as: ACACT & ACAT.
Papers published on a yearly basis
Papers
TL;DR: The roles of the Niemann-Pick type C1 protein in mediating the endosomal transport of LDL-derived cholesterol and endogenously synthesized cholesterol are discussed and a close relationship between the ACAT substrate pool and the cholesterol efflux pool is proposed.
Abstract: Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from endogenous biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the endosomal transport of LDL-derived cholesterol and endogenously synthesized cholesterol are discussed. Excess cellular cholesterol is converted to cholesteryl esters by the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) 1 or is removed from a cell by cellular cholesterol efflux at the plasma membrane. A close relationship between the ACAT substrate pool and the cholesterol efflux pool is proposed. Sterol-sensing domains (SSDs) are present in several membrane proteins, including NPC1, HMG-CoA reductase, and the SREBP cleavage-activating protein. The functions of SSDs are described. ACAT1 is an endoplasmic reticulum cholesterol sensor and contains a signature motif characteristic of the membrane-bound acyltransferase family. The nonvesicular cholesterol translocation processes involve the START domain proteins and the oxysterol binding protein-related proteins (ORPs). The properties of these proteins are summarized.
630 citations
TL;DR: In this paper, the authors summarized the current knowledge on ACAT-related research in two areas: ACAT genes and proteins and ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
Abstract: The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
435 citations
TL;DR: It is speculated that ARGP1 participates in the coenzyme A-dependent acylation of substrate(s) other than cholesterol, and unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylations in triglyceride biosynthesis.
430 citations
TL;DR: It is demonstrated that two different forms of the intracellular cholesterol esterification enzyme acyl-CoA:cholesterol acyltransferase (ACAT) are present in the nonhuman primate hepatocyte and topologic predictions from the amino acid sequence of ACAT2 indicates that this enzyme may have as a primary function, the secretion of cholesteryl esters into apoB-containing lipoproteins.
323 citations
TL;DR: The roles of cholesterol and its metabolites, and the latest advances in cancer therapy targeting cholesterol metabolism are reviewed.
293 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 6 |
| 2020 | 14 |
| 2019 | 7 |
| 2018 | 8 |
| 2017 | 6 |
| 2016 | 5 |