Topic
Simaba cedron
About: Simaba cedron is a research topic. Over the lifetime, 7 publications have been published within this topic receiving 213 citations.
Papers
TL;DR: An IN VITRO antimalarial test, utilising the inhibition of uptake of [G- 3 H]-hypoxanthine into PLASMODIUM FALCIPARUM cultured in human blood, has been used to assess the activity of crude extracts of ARTEMISIA ANNUA and A. VULGARIS.
Abstract: An IN VITRO antimalarial test, utilising the inhibition of uptake of [G- (3)H]-hypoxanthine into PLASMODIUM FALCIPARUM cultured in human blood, has been used to assess the activity of crude extracts of ARTEMISIA ANNUA and A. VULGARIS (Compositae) and of BRUCEA JAVANICA, AILANTHUS ALTISSIMA, and SIMABA CEDRON (Simaroubaceae).
143 citations
TL;DR: Cedronin belongs to the small group of quassinoids with a C19 basic skeleton and shows a rather low cytotoxicity against KB cells, as compared with C20 biologically active quassinoid; however its toxic/therapeutic ratio remains lower than chloroquine.
37 citations
TL;DR: Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparin (7), glaucarubolone (8, glauCarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the
Abstract: Four new quassinoids, cedronolactones A−D (1−4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1−4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 μg/mL) against P-388 cells.
32 citations
TL;DR: A novel pentacyclic C(19) quassinoid, cedronolactone E (1), was isolated from the wood of Simaba cedRON and its structure was elucidated by interpretation of spectroscopic data.
Abstract: A novel pentacyclic C19 quassinoid, cedronolactone E (1), was isolated from the wood of Simaba cedron. Its structure was elucidated by interpretation of spectroscopic data.
11 citations
Journal Article•
9 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2001 | 1 |
| 1998 | 2 |
| 1994 | 1 |
| 1985 | 1 |
| 1963 | 1 |
| 1960 | 1 |