TL;DR: Primary Silastic medialization significantly decreases the postoperative rehabilitation period in skull base patients because of the immediate postoperative glottal competence and decreased use of perioperative tracheotomy.
Abstract: From April 1987 to April 1992, 116 phonosurgical procedures were performed to treat glottal incompetence. The initial numbers of these surgical procedures included the following: 29 primary Silastic medializations, 3 primary Silastic medializations with arytenoid adduction, 53 secondary Silastic medializations, 4 secondary Silastic medializations with arytenoid adduction, and 11 bilateral Silastic medializations. These procedures are useful in treating unilateral true vocal cord paralysis, scarring, bowing, or paresis, as well as bilateral true vocal cord bowing. Of the initial 100 patients, 16 later underwent a revision with either a larger implant's being placed or an arytenoid adduction. Primary Silastic medialization is the placement of an implant under general anesthesia in the same surgical setting in which laryngeal innervation is sacrificed. Secondary Silastic medialization is the placement of an implant under local anesthesia for a preexistent vocal cord malfunction. In either case, overall voice results for unilateral paralysis are very good. Primary Silastic medialization significantly decreases the postoperative rehabilitation period in skull base patients because of the immediate postoperative glottal competence and decreased use of perioperative tracheotomy. Bilateral implants yielded good results in 6 patients with presbylaryngis, but 6 other patients with bowing from other causes experienced only moderate improvement in speech quality. There were no implant extrusions; however, 1 implant was removed secondary to a persistent laryngocutaneous fistula in a patient who had previously undergone laryngeal irradiation. This was the only complication in this series.
TL;DR: An animal model was used in which finely ground particulate silicone elastomer was introduced into the knee joints of adult New Zealand White rabbits, and histological evidence of inflammatory changes developed in the synovial tissue, similar to those seen in patients.
Abstract: A reactive synovitis secondary to intra-articular particles of silicone elastomer developed in three patients who had undergone Silastic hemiarthroplasty. In an attempt to duplicate this phenomenon, we used an animal model in which finely ground particulate silicone elastomer was introduced into the knee joints of adult New Zealand White rabbits. In three of thirteen rabbits (p = 0.066) histological evidence of inflammatory changes developed in the synovial tissue, similar to those seen in our patients. Intraarticular particulate silicone elastomer created by abrasion of a Silastic hemiarthroplasty may be responsible for the development of an iatrogenic reactive synovitis.
TL;DR: These data confirm what has been observed clinically, that in the population studied, multiply operated patients previously exposed to failed ProPlast-Teflon alone or both failed Proplast-teflon and Silastic have poorer reported long-term outcomes with alloplastic reconstruction.
TL;DR: Because there was a clinically significant rate of removal of this material, consideration should be given to the use of other available materials.