Topic
Shvo catalyst
About: Shvo catalyst is a research topic. Over the lifetime, 39 publications have been published within this topic receiving 1820 citations.
Papers
TL;DR: This paper presents a meta-analysis of existing and proposed mechanisms for kinetic Isotope Effect Studies, and some new ones proposed, which aim to investigate the role of phosphine-Substituted Homologue in this effect.
Abstract: 7.1. Proposed Mechanisms 2306 7.2. Kinetic Isotope Effect Studies 2306 7.3. Amine Coordination and Exchange 2306 7.4. Computational Studies 2307 7.5. Summary 2307 8. Analogous Systems 2308 8.1. Structural Analogues 2308 8.1.1. Cyclopentadienyl Amine Derivatives 2308 8.1.2. μ-Iodo Homologue 2308 8.1.3. Silica-Supported Homologue 2309 8.1.4. Phosphine-Substituted Homologue 2309 8.2. Osmium 2309 8.3. Iron 2310 9. Outlook 2311 10. Acknowledgments 2311 11. References 2311
398 citations
TL;DR: A novel and convenient protocol for the catalytic hydrogen-deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodology has been developed and constitutes a powerful tool for the generation of valuable internal standard materials for LC-MS/MS analyses highly demanded for various life-science applications.
Abstract: A novel and convenient protocol for the catalytic hydrogen-deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodology has been developed. In the presence of the readily available Shvo catalyst, excellent chemoselectivity toward α- and β-protons with respect to the nitrogen atom as well as high degree of deuterium incorporation and functional group tolerance is achieved. This allowed for the deuteration of complex pharmaceutically interesting substrates, including examples for actual marketed drug compounds. Notably, this method constitutes a powerful tool for the generation of valuable internal standard materials for LC-MS/MS analyses highly demanded for various life-science applications.
159 citations
TL;DR: Shvo's diruthenium complex is an active catalyst in a considerable number of homogeneous reactions and its catalytic activity is mainly due to the fact that it dissociates into two monomeric ruthensium species in solution under thermal conditions as mentioned in this paper.
139 citations
TL;DR: The Shvo catalyst is one of the most prominent examples of a hydrogen-transfer catalyst successfully applied in a broad scope of hydrogen transfer processes, but the reaction mechanism for the hydrogen transfer process is a matter of controversy as mentioned in this paper.
133 citations
TL;DR: In this article, the Shvo catalyst has been shown to transfer almost simultaneously a proton from the hydroxycyclopentadienyl ligand and a hydride bonded to the metal center.
94 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 3 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 3 |
| 2015 | 1 |