Topic
Shellfish poisoning
About: Shellfish poisoning is a research topic. Over the lifetime, 856 publications have been published within this topic receiving 27219 citations. The topic is also known as: Shellfish poisoning.
Papers published on a yearly basis
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Papers
TL;DR: The recent elucidation of the saxitoxin biosynthetic gene cluster in cyanobacteria and the identification of new PST analogs will present opportunities to further explore the pharmaceutical potential of these intriguing alkaloids.
Abstract: Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of paralytic shellfish poisoning (PSP) and are mostly associated with marine dinoflagellates (eukaryotes) and freshwater cyanobacteria (prokaryotes), which form extensive blooms around the world. PST producing dinoflagellates belong to the genera Alexandrium, Gymnodinium and Pyrodinium whilst production has been identified in several cyanobacterial genera including Anabaena, Cylindrospermopsis, Aphanizomenon Planktothrix and Lyngbya. STX and its analogs can be structurally classified into several classes such as non-sulfated, mono-sulfated, di-sulfated, decarbamoylated and the recently discovered hydrophobic analogs—each with varying levels of toxicity. Biotransformation of the PSTs into other PST analogs has been identified within marine invertebrates, humans and bacteria. An improved understanding of PST transformation into less toxic analogs and degradation, both chemically or enzymatically, will be important for the development of methods for the detoxification of contaminated water supplies and of shellfish destined for consumption. Some PSTs also have demonstrated pharmaceutical potential as a long-term anesthetic in the treatment of anal fissures and for chronic tension-type headache. The recent elucidation of the saxitoxin biosynthetic gene cluster in cyanobacteria and the identification of new PST analogs will present opportunities to further explore the pharmaceutical potential of these intriguing alkaloids.
705 citations
TL;DR: In this article, the causative agents of a new type of shellfish poisoning, named diarrhea-shellfish poisoning were identified, namely, 35(S)-methylokadaic acid, 7-O-acyl derivatives of 35S-methylkadaic acids, two novel polyether lactones named pectenotoxin-1 and -2 have been isolated and had their structures determined.
620 citations
Book•
1 Jan 1993
TL;DR: Some Taxonomic and Biologic Aspects of Toxic Dinoflagellates and Toxic Cyanophycea (Cyanobacteria).
Abstract: Some Taxonomic and Biologic Aspects of Toxic Dinoflagellates. Methods of Analysis for Algal Toxins: Dinoflagellate and Diatom Toxins. Mode of Action of Toxins of Shellfish Poisoning. Paralytic Shellfish Poisoning. Diarrhetic Shellfish Poisoning. Ciguatera Fish Poisoning. Control Measures in Shellfish and Finfish Industries: U.S.A. Seafood Toxins of Algal Origin and Their Control in Canada. Taxonomy of Toxic Cyanophycea (Cyanobacteria). Measurement of Toxins from Blue-Green Algae in Water and Foodstuffs. Mechanism of Toxicity of Cyclic Peptide Toxins from Blue-Green Algae. Disease Related to Freshwater Algal Blooms.
577 citations
TL;DR: This is a critical review of the global distribution, sources of variation in toxicity, anatomical partitioning, metabolism, and detoxification kinetics of paralytic shellfish poisoning (PSP) toxins (carbamate, TV-sulfocarbamoyl, and decarbamoysl saxitoxin derivatives) in bivalve molluscs.
Abstract: This is a critical review of the global distribution, sources of variation in toxicity, anatomical partitioning, metabolism, and detoxification kinetics of paralytic shellfish poisoning (PSP) toxins (carbamate, TV-sulfocarbamoyl, and decarbamoyl saxitoxin derivatives) in bivalve molluscs. Marked interspecific differences in toxin accumulation are related to differences in toxin sensitivity, determined from neurological, physiological, and behavioral responses. Toxicity also varies considerably with body size, immersion time, off-bottom position, and over distances ≤1 km. Bivalve species can be broadly classified as rapid (e.g., Mytilus eduJis) or slow detoxifiers (e.g., Placopecten mageJJanicus). The former takes weeks to detoxify to the regulatory level (up to 15% toxin loss day−1); the latter takes months to years to detoxify (≤3% loss day−1). Toxin biotransformation, which may lead to changes in net toxicity, varies greatly among species. A few clam species, such as Protothaca staminea and Spisula soli...
508 citations
24 Aug 2000
TL;DR: Part I General Considerations Dinoflagellate Toxins: An Overview Michael J. Holmes, Andreas Brust, and Richard J. Lewis Guide to Phycotoxin Monitoring of Bivalve Mollusk-Harvesting Areas Luis M. Thomas Emerging Toxic Cyanobacterial Issues in Freshwater Sources: Influence of Climate Change Arash Zamyadi
Abstract: General Considerations Risk Assessment of Marine Toxins, T. Aune Analysis of Marine Toxins - Techniques, Method Validation, Calibration Standards and Screening Methods, P. Holland The Epidemiological Impact of Toxic Episodes Diarrheic Toxins, J. Gestal Neurotoxic Toxins, B. Gessner and J.B. McLaughlin Diversity of Marine Toxins as Pharmacological Tools Calcium Channels for Exocytosis: Functional Modulation with Toxins, A. Garcia The Mouse Bioassay as a Universal Detector, L.M Botana Paralytic Shellfish Poisoning (PSP) Metabolism of Paralytic Shellfish Toxins Incorporated into Bivalve, M. Kodama Chemical Analysis, B. Ben and A. Villar Pharmacology and Toxicology: Biological Detection Methods, B. Suarez Diarrheic Episodes: Phosphatase Inhibitors. Chemistry, Metabolism, Chemical Analysis of OA Group Toxins, P. MacNabb Pharmacology and Toxicology, A. Tubaro Lipophyllic Toxins: Non-phosphatase Inhibitors Planktonic Dinoflagellates which Produce Polyether Toxins of the Old "DSP Complex", B. Reguera Yessotoxins Chemistry, Metabolism, Chemical Analysis, E. Fatorusso and P. Ciminello Pharmacology and Mechanism of Action: Biological Detection, A. Alfonso Toxicology of the Yessotoxins, R. Munday Pectenotoxins Chemistry, Metabolism, and Chemical Detection Methods of Pectenotoxins, T. Suzuki Pharmacology of Pectenotoxins, N. Vilarino Toxicology of Pectenotoxins, R. Munday Domoic Acid Intoxication Ecobiology of ASP Producing Diatoms, Y. Kotaki Domoic Acid: Detection Methods, Pharmacology and Toxicology, A. Tasker Non-PSP Neurotoxic Episodes The Ecobiology of the Brevetoxin, Ciguatoxin and Cyclic Imine Producers, L. Mackenzie Ciguatera Toxins Ciguatera Toxins: Chemistry, Toxicology and Detection, R. Dickey Maitotoxin Maitotoxin: a Unique Pharmacological T ool for Elucidating Ca2+-Dependent Mechanisms, A. Darszon Brevetoxins The Molecular and Integrative Basis to Brevetoxin Toxicity, J. Ramsdell Dection of Brevetoxins in the 21st Century, M. Poli Cyclic Imines and Spirolides Cyclic Imine Toxins: Chemistry, Biogeography, Biosynthesis and Pharmacology, A. Cembella Toxicology of Cyclic Imines: Gymnodimine, Spirolides, Pinnatoxins, Pteriatoxins, Prorocentrolide, Spiro-Prorpcentrimine, and Symbiomines, R. Munday Polycavernosides: Gambierol Polycavernosides: Gambierol, Chemistry, Pharmacology, Toxicology, and Detection, C. Louzao Palytoxin, Ostreocin, Ovatatoxin Palytoxin and Analogues: Ecobiology and Origin. Chemistry, Metabolism and Chemical Analisis, P. Katikou Diverse Chemical Structures and Bioactivities of Marine Toxin: Palytoxin and Symbiodinolide, D.Uemura Palytoxins: Pharmacology and Biological Detection Methods, C. Vale Occurrence and Toxicology of Palytoxins, R. Munday Pfiesteria Toxins Pfiesteria spp. Toxins: Unresolved Questions and an Alternative Hypotheses, G. Vasta and A. Place Azaspiracids Pharmacology and Epidemiological Impact of Azaspiracids, M. Ryan Azaspiracids: Chemistry, Bioconversion and Determination, K. James Toxicology of Azaspiracid 1, E. Ito Cyanobacterial Toxins Cyanobacterial Toxins in Aquaculture, P.T Smith Neurotoxins Cyanobacterial Neurotoxins, Anatoxin-a and Analogues: Detection and Analysis, K. James Hepatotoxins Cyanobacterial Hepatotoxins: Chemistry, Biosynthesis, and Occurrence, M. Welker Hepatotoxins: Context and Chemical Determination, K. James Toxins as a Starting Point to Drugs Marine Neurotoxins as a Starting Point to Drugs, M.R. Waters Legal and Economical Views Incidence of Marine Toxins on Industrial Activity, J M Vieites Toxin Monitoring Programs and Regulatory View, M.L. Rodriguez-Velasco
399 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 12 |
| 2024 | 14 |
| 2023 | 23 |
| 2022 | 45 |
| 2021 | 45 |
| 2020 | 39 |