Topic
SENP1
About: SENP1 is a research topic. Over the lifetime, 157 publications have been published within this topic receiving 12255 citations. The topic is also known as: SuPr-2 & SUMO1/sentrin specific peptidase 1.
Papers published on a yearly basis
Papers
TL;DR: The current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes are discussed.
Abstract: ▪ Abstract Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction. Reversible attachment of SUMO is controlled by an enzyme pathway that is analogous to the ubiquitin pathway. The functional consequences of SUMO attachment vary greatly from substrate to substrate, and in many cases are not understood at the molecular level. Frequently SUMO alters interactions of substrates with other proteins or with DNA, but SUMO can also act by blocking ubiquitin attachment sites. An unusual feature of SUMO modification is that, for most substrates, only a small fraction of the substrate is sumoylated at any given time. This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a...
1,778 citations
TL;DR: The diverse effects of SUMO modification are discussed and models proposed to explain SUMO actions.
1,742 citations
TL;DR: A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function ofsumO and substrate conjugation in distinct cellular pathways.
Abstract: Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have emerged. Although SUMO-conjugating enzymes can discriminate between SUMO targets, many substrates possess characteristics that facilitate their modification. Other post-translational modifications also regulate SUMO conjugation, suggesting that SUMO signalling is integrated with other signal transduction pathways. A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function of SUMO and substrate conjugation in distinct cellular pathways.
1,104 citations
TL;DR: The results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1α stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation.
616 citations
TL;DR: The dissimilar sub-nuclear localization patterns of Ulp/SENPs and phenotypes of UlP/SenP mutants further indicate that different Ulp and SENPs have distinct and non-redundant roles.
593 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 6 |
| 2020 | 6 |
| 2019 | 8 |
| 2018 | 6 |
| 2017 | 8 |
| 2016 | 15 |