Topic
Securidaca
About: Securidaca is a research topic. Over the lifetime, 97 publications have been published within this topic receiving 1317 citations.
Papers published on a yearly basis
Papers
TL;DR: The root bark extracts of the three plants showed antibacterial activity, justifying their continued use in treatment of bacterial infections.
Abstract: Background: Nearly all cultures from ancient times to the present day have used plants as a source of medicines. As a result, different remedies tended to develop in different parts of the world. Current strategies to overcome the global problem of antimicrobial resistance include research in finding new and innovative antimicrobials from plants. Objectives: To determine the antibacterial activity of extracts of Annona senegalensis, Securidacca longipendiculata and Steganotaenia araliacea, plants which are used in Eastern Uganda for the treatment of diarrhea and wound infections. Methods: The root barks of these plants were collected, sun-dried, pounded using pestles and wooden mortars. Water and methanol extracts were derived and screened. Standard cultures of E. coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923 were used in the study. The antibacterial tests used were the agar well diffusion assays. The minimum inhibitory concentrations (MIC) were determined by cylinder plate technique. Results: Extracts of Annona senegalensis, Steganotaenia araliacea and Securidaca longipendiculata showed activity against Staphylococcus aureus. The methanol extract of Securidaca longipediculata was not inhibitory to S.aureus. Steganotaenia araliacea and Securidaca longipediculata (water) extracts were active against all the bacteria tested. The water and methanol extracts of Annona senegalensis did not show inhibitory activity against E. coli. Of the three bacteria studied, Staphylococcus aureus was the most susceptible to the extracts followed by P. aeruginosa. E. coli was least sensitive to the plant extracts. Annona senegalensis had the lowest MIC against Staphylococcus aureus (62.5mg/ml); while Steganotaenia araliacea had the highest MIC (250mg/ml) signifying lower activity. Conclusions: The root bark extracts of the three plants showed antibacterial activity, justifying their continued use in treatment of bacterial infections. Recommendations: Further studies are required to isolate and characterise the active phytochemical constituents in the plants. Toxicity studies should be done to determine their safety. African Health Sciences 2006; 6(1): 31-35
139 citations
TL;DR: The results obtained indicate that the aqueous root extract of Securidaca longepedunculata has central nervous system depressant and anxiolytic activities that justify the use of the extract in traditional medicine for the management of convulsion and psychosis.
91 citations
TL;DR: Results suggest that S. securidaca seed in addition to decrease lipid levels and peroxidation, is able to improve vascular endothelium-dependent relaxation in hypercholesterolemia.
90 citations
TL;DR: Extensive exposure for 6 days showed that lower amounts of methyl salicylate vapor were able to induce 100% adult mortality of the three insect species, and the implications are discussed in the context of improving stored product pest control by small-scale subsistence farmers in Africa.
Abstract: Securidaca longepedunculata Fers (Polygalaceae) is commonly used as a traditional medicine in many parts of Africa as well as against a number of invertebrate pests, including insects infesting stored grain. The present study showed that S. longepedunculata root powder, its methanol extract, and the main volatile component, methyl salicylate, exhibit repellent and toxic properties to Sitophilus zeamais adults. Adult S. zeamais that were given a choice between untreated maize and maize treated with root powder, extract, or synthetic methyl salicylate in a four-way choice olfactometer significantly preferred the control maize. Methyl salicylate vapor also had a dose-dependant fumigant effect against S. zeamais, Rhyzopertha dominica, and Prostephanus truncates, with a LD100 achieved with a 60 μl dose in a 1-l container against all three insect species after 24 hr of exposure. Probit analyses estimated LD50 values between 34 and 36 μl (95% CI) for all insect species. Furthermore, prolonged exposure for 6 days showed that lower amounts (30 μl) of methyl salicylate vapor were able to induce 100% adult mortality of the three insect species. The implications are discussed in the context of improving stored product pest control by small-scale subsistence farmers in Africa.
79 citations
TL;DR: The potential to optimize the use of this plant for stored product protection using water extracts, which would be appropriate technology for target farmers, is discussed.
Abstract: Powdered dry root bark of Securidaca longepedunculata was mixed with maize and cowpea and effectively reduced the numbers of Sitophilus zeamais and Callosobruchus maculatus emerging from these commodities, respectively, more than 9 months after treatment. This effect was reciprocated in grain treated with a methanol extract of the root bark, indicating that compounds were present that were oviposition deterrents or directly toxic to the adults or larvae. Two new bisdesmosidic saponins, 3-O-β-Dglucopyranosyl-28-O-(R-L-arabinopyranosyl-(1f3)-β-D-xylopyranosyl-(1 f 4)[β-D-apiofuranosyl-(1 f 3)]R-L-rhamnopyranosyl-(1 f 2)-[4-O-(4-methoxycinnamoyl-β-D-fucopyranosyl)])-medicagenic acid (securidacaside A) and 3-O-β-D-glucopyranosyl-28-O-(R-L-arabinopyranosyl-(1f3)-β-D-xylopyranosyl-(1 f 4)[β-D-apiofuranosyl-(1f3)]-R-L-rhamnopyranosyl-(1f2)-[4-O-(3,4,5-trimethoxy-(E)-cinnamoyl-β-D-fucopyranosyl)])-medicagenic acid (securidacaside B), were isolated from the methanol extract of the roots of S. longepedunculata and characterized by spectroscopic methods. Securidacaside A, which occurred as (E) -a nd(Z)-regioisomers, showed deterrency and toxicity toward C. maculatus and S. zeamais and could contribute to the biological activity of the methanol extract. The potential to optimize the use of this plant for stored product protection using water extracts, which would be appropriate technology for target farmers, is discussed.
61 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 2 |
| 2019 | 7 |
| 2018 | 4 |
| 2017 | 6 |
| 2016 | 1 |