Topic
Scrub typhus
About: Scrub typhus is a research topic. Over the lifetime, 2629 publications have been published within this topic receiving 39784 citations. The topic is also known as: Tsutsugamushi & tsutsugamushi disease.
Papers published on a yearly basis
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Papers
TL;DR: DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity and should be included in any potential vaccine.
Abstract: Orientia tsutsugamushi is the etiological agent of scrub typhus, an acute, mite-borne, febrile illness that occurs in the Asia-Pacific region. Historically, strain characterization used serological analysis and revealed dramatic antigenic diversity. Eyeing a recommendation of potential vaccine candidates for broad protection, we review geographic diversity and serological and DNA prevalences. DNA analysis together with immunological analysis suggest that the prototype Karp strain and closely related strains are the most common throughout the region of endemicity. According to serological analysis, ∼50% of isolates are seroreactive to Karp antisera, and approximately one-quarter of isolates are seroreactive to antisera against the prototype Gilliam strain. Molecular methods reveal greater diversity. By molecular methods, strains phylogenetically similar to Karp make up ∼40% of all genotyped isolates, followed by the JG genotype group (Japan strains serotypically similar to the Gilliam strain but genetically non-Gilliam; 18% of all genotyped isolates). Three other genotype groups (Katorelated, Kawasaki-like, and TA763-like) each represent ∼10% of genotyped isolates. Strains genetically similar to the Gilliam strain make up only 5% of isolates. Strains from these groups should be included in any potential vaccine.
485 citations
TL;DR: Five main antigenic groups that cause Typhus, spotted fever, scrub typhus, Q Fever, Q fever, and trench fever are identified.
Abstract: RICKETTSIA that are pathogenic for humans include five main antigenic groups that cause, respectively, typhus, spotted fever, scrub typhus, Q fever, and trench fever.1 There is also a group of intr...
482 citations
TL;DR: R Rash and fever in a returning traveler could be rickettsial and presumptive doxycycline treatment can be curative, and African tick-bite fever appears to be of particular importance to travellers.
Abstract: Purpose of reviewRecent developments in molecular taxonomic methods have led to a reclassification of rickettsial diseases. The agent responsible for scrub typhus (Orientia tsutsugamushi) has been removed from the genus Rickettsia and a bewildering array of new rickettsial pathogens have been descri
469 citations
TL;DR: The objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection.
Abstract: Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas. Our objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection.
420 citations
TL;DR: Results show that the untreated mortality from scrub typhus appears lower than previously reported estimates, and more data are required to clarify mortality according to location and host factors, clinical syndromes including myocarditis and central nervous system disease, and in vulnerable mother-child populations.
Abstract: Background
Scrub typhus, a bacterial infection caused by Orientia tsutsugamushi, is increasingly recognized as an important cause of fever in Asia, with an estimated one million infections occurring each year. Limited access to health care and the disease’s non-specific symptoms mean that many patients are undiagnosed and untreated, but the mortality from untreated scrub typhus is unknown. This review systematically summarizes the literature on the untreated mortality from scrub typhus and disease outcomes.
314 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 106 |
| 2024 | 244 |
| 2023 | 197 |
| 2022 | 277 |
| 2021 | 151 |
| 2020 | 149 |