Topic
Scad
About: Scad is a research topic. Over the lifetime, 92 publications have been published within this topic receiving 4280 citations.
Papers published on a yearly basis
Papers
TL;DR: High rates of recurrent SCAD; its association with female sex, pregnancy, and physical and emotional stress triggers; and concurrent systemic arteriopathies, particularly fibromuscular dysplasia highlight the differences in clinical characteristics of SCAD compared with atherosclerotic disease.
Abstract: Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than previously believed but also must be evaluated and treated differently from atherosclerotic myocardial infarction. High rates of recurrent SCAD; its association with female sex, pregnancy, and physical and emotional stress triggers; and concurrent systemic arteriopathies, particularly fibromuscular dysplasia, highlight the differences in clinical characteristics of SCAD compared with atherosclerotic disease. Recent insights into the causes of, clinical course of, treatment options for, outcomes of, and associated conditions of SCAD and the many persistent knowledge gaps are presented.
1,039 citations
TL;DR: Although in-hospital mortality is low regardless of initial treatment, percutaneous coronary intervention is associated with high rates of complication, and the need for close follow-up is emphasized.
Abstract: Background—Spontaneous coronary artery dissection (SCAD) is an acute coronary event of uncertain origin. Clinical features and prognosis remain insufficiently characterized. Methods and Results—A retrospective single-center cohort study identified 87 patients with angiographically confirmed SCAD. Incidence, clinical characteristics, treatment modalities, in-hospital outcomes, and long-term risk of SCAD recurrence or major adverse cardiac events were evaluated. Mean age was 42.6 years; 82% were female. Extreme exertion at SCAD onset was more frequent in men (7 of 16 versus 2 of 71; P<0.001), and postpartum status was observed in 13 of 71 women (18%). Presentation was ST-elevation myocardial infarction in 49%. Multivessel SCAD was found in 23%. Initial conservative management (31 of 87) and coronary artery bypass grafting (7 of 87) were associated with an uncomplicated in-hospital course, whereas percutaneous coronary intervention was complicated by technical failure in 15 of 43 patients (35%) and 1 death. ...
899 citations
TL;DR: Hypertension increased the risk of recurrent SCAD, whereas beta-blocker therapy appeared to be protective, and long-term cardiovascular events were common in the large prospectively followed SCAD cohort.
545 citations
TL;DR: A clinical update on the diagnosis and management of patients with SCAD is provided, including pregnancy-associated SCAD and pregnancy after SCAD, and high-priority knowledge gaps that must be addressed are highlighted.
357 citations
TL;DR: An efficient optimization algorithm is developed that is fast and always converges to a local minimum and it is proved that the SCAD estimator still has the oracle property on high-dimensional problems.
Abstract: The smoothly clipped absolute deviation (SCAD) estimator, proposed by Fan and Li, has many desirable properties, including continuity, sparsity, and unbiasedness. The SCAD estimator also has the (asymptotically) oracle property when the dimension of covariates is fixed or diverges more slowly than the sample size. In this article we study the SCAD estimator in high-dimensional settings where the dimension of covariates can be much larger than the sample size. First, we develop an efficient optimization algorithm that is fast and always converges to a local minimum. Second, we prove that the SCAD estimator still has the oracle property on high-dimensional problems. We perform numerical studies to compare the SCAD estimator with the LASSO and SIS–SCAD estimators in terms of prediction accuracy and variable selectivity when the true model is sparse. Through the simulation, we show that the variance estimator of Fan and Li still works well for some limited high-dimensional cases where the true nonzero coeffic...
306 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 46 |
| 2024 | 96 |
| 2023 | 120 |
| 2022 | 174 |
| 2021 | 31 |
| 2020 | 15 |