Topic
Rubiscolin
About: Rubiscolin is a research topic. Over the lifetime, 17 publications have been published within this topic receiving 483 citations. The topic is also known as: rubiscolins.
Papers
TL;DR: Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were obtained and new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.
108 citations
TL;DR: This is the first example of bioactive peptides derived from plant Rubisco, which have antinociceptive activity in mice after i.c.v. or oral administration and were selective for δ receptor.
101 citations
TL;DR: It is shown that intraperitoneally or orally administered rubiscolin-6 has an anxiolytic effect at a dose of 10 mg/kg or 100 mg/kg, respectively, in the elevated plus-maze test in mice, and that this effect is mediated by σ 1 and dopamine D 1 receptors downstream of δ opioid receptor.
90 citations
TL;DR: 3D-QSAR studies identified that the potency of delta opioid activity of rubiscolin analogues essentially exhibited a significant relationship with local hydrophobic and hydrophilic characteristics of amino acids at positions 3, 4, 5, and 6.
Abstract: Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were carried out on a series of 38 rubiscolins as delta opioid peptides using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). Quantitative information on structure-activity relationships is provided for further rational development and direction of selective synthesis. All models were carried out over a training set including 30 peptides. The best CoMFA model included electrostatic and steric fields and had a moderate Q (2) = 0.503. CoMSIA analysis surpassed the CoMFA results: the best CoMSIA model included only the hydrophobic field and had a Q (2) = 0.661. In addition, this model predicted adequately the peptides contained in the test set. Our model identified that the potency of delta opioid activity of rubiscolin analogues essentially exhibited a significant relationship with local hydrophobic and hydrophilic characteristics of amino acids at positions 3, 4, 5, and 6.
39 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 1 |
| 2019 | 3 |
| 2018 | 2 |
| 2015 | 1 |
| 2014 | 1 |
| 2013 | 1 |