About: Rhodesian Ridgeback is a research topic. Over the lifetime, 32 publications have been published within this topic receiving 337 citations. The topic is also known as: African Lion Dog & Van Rooyen's Lion Dog.
TL;DR: The authors have investigated the inheritance of the condition and, contrary to the hypotheses of others, suggest that it is a simple recessive character.
Abstract: —The Rhodesian Ridgeback is a modern breed having been standardized in 1922. It originated in South Africa by crossing Hottentot dogs with various European breeds. The breed has one defect, a congenital malformation, generally known as dermoid sinus. The authors have investigated the inheritance of the condition and, contrary to the hypotheses of others, suggest that it is a simple recessive character. The implications of this are discussed.
Reslame—Le chien de Rhodesie, denomme Ridgeback, est d'un elevage recent, bien etabli depuis 1922. II est originaire d'Afrique du Sud, resultant d'un croisement de chiens Hottentots et de divers chiens europeens. Cette souche a un defaut, une malformation congenitale generalement designee kyste dermoide. Les auteurs ont recherches l'heredite de cette condition, et contrairement a d'autres hypotheses, ils suggerent qu'il s'agit d'un caractere hereditaire recessif. Les consequences en sont discutees.
Zusammenfassung—Der Rhodesische “Ridgeback’ ist eine neuzeitliche Zucht, die im Jahre 1922 standardisiert wurde. Ihr Ursprung ist in Sued Afrika, vollzogen durch Kreuzung von Hottentotten Hunden mit verschiedenen europaeischen Rassen. Der “Ridgeback’ hat einen Fehler: eine congeni-tale Missbildung, die allgemein als “Dermoid Sinus’ bekannt ist.
Die Autoren haben die Vererbung dieses Zustandes untersucht und schlagen vor, entgegen den Hypothesen anderer Autoren, sie als ein einfaches, recessives Merkmal zu bezeichnen.
Die sich daraus ergebenden Beziehungen werden eroertert.
TL;DR: A case of a true dermoid cyst in a Rhodesian ridgeback is described, which was located in the dorsal cervical midline at the level of the first cervical vertebra, and was resected surgically.
Abstract: A case of a true dermoid cyst in a Rhodesian ridgeback is described. The mass was located in the dorsal cervical midline at the level of the first cervical vertebra, and was resected surgically. In contrast to other types of dermoid sinus described in the literature, the mass did not have a tract connecting it to, nor an opening on to, the surface of the skin. A diagnosis of true dermoid cyst was made.
TL;DR: A 4-year-old neutered Rhodesian ridgeback/dalmatian crossbred bitch was presented with a cervical, dorsal midline cutaneous swelling after 2 unsuccessful attempts at surgical resection of a dermoid sinus.
Abstract: A 4-year-old neutered Rhodesian ridgeback/dalmatian crossbred bitch was presented with a cervical, dorsal midline cutaneous swelling after 2 unsuccessful attempts at surgical resection of a dermoid sinus. Radiographs of the cervical spine indicated a C2 transosseous communication with the vertebral canal. Ultrasonographic evaluation demonstrated 2 interlinking cavities terminating close to C2. Complete resection of the sinus tract necessitated a partial dorsal laminectomy. Histology confirmed the diagnosis. This case is compared to similar cases in the literature.
TL;DR: The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus and Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoids sinus.
Abstract: Objectives: To define the mode of inheritance of the dorsal ridge and investigate if the ridge predisposes to the congenital abnormality dermoid sinus in the Rhodesian ridgeback.
Methods: Segregation analysis was performed, including 87 litters (n=803) produced in Sweden between 1981 and 2002. Data were corrected to avoid bias in the segregation ratio. Chi-squared analysis was performed including 402 litters (n=3598) for the evaluation of a possible genetic correlation between the ridge and dermoid sinus.
Results: The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus. The frequency of ridgeless offspring in the Swedish Rhodesian ridgeback population is estimated to be 5·6 per cent.
Clinical Significance: Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoid sinus.
TL;DR: A syndrome of cerebellar Purkinje's cell degeneration and coat color dilution was diagnosed in a family of Rhodesian Ridgeback dogs and an autosomal recessive mode of inheritance was suggested.
Abstract: A syndrome of cerebellar Purkinje's cell degeneration and coat color dilution was diagnosed in a family of Rhodesian Ridgeback dogs. One male and 1 female from the same litter and 1 female from a different litter were evaluated for growth retardation, inability to ambulate, and progressive ataxia. On physical examination, lateral recumbency, severe ataxia, tremors, and diluted coat color were identified. Littermates with nondiluted coat color were neurologically normal. Results of routine laboratory tests, urine metabolic screenings, and karyotype analyses were normal. Histopathologic abnormalities at necropsy included cerebellar Purkinje's cell degeneration, reduced granular cell layer thickness, and uneven distribution of macromelanosomes within hair shafts. Pedigree analysis suggested an autosomal recessive mode of inheritance. This is the first description of a genetic syndrome affecting the central nervous system and associated with coat color dilution in dogs.