Respiratory function

Abstract: Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses (CoVs) have a proclivity to spread rapidly into new host species causing severe disease. Severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) successively emerged, causing severe epidemic respiratory disease in immunologically naive human populations throughout the globe. Broad-spectrum therapies capable of inhibiting CoV infections would address an immediate unmet medical need and could be invaluable in the treatment of emerging and endemic CoV infections. We show that a nucleotide prodrug, GS-5734, currently in clinical development for treatment of Ebola virus disease, can inhibit SARS-CoV and MERS-CoV replication in multiple in vitro systems, including primary human airway epithelial cell cultures with submicromolar IC50 values. GS-5734 was also effective against bat CoVs, prepandemic bat CoVs, and circulating contemporary human CoV in primary human lung cells, thus demonstrating broad-spectrum anti-CoV activity. In a mouse model of SARS-CoV pathogenesis, prophylactic and early therapeutic administration of GS-5734 significantly reduced lung viral load and improved clinical signs of disease as well as respiratory function. These data provide substantive evidence that GS-5734 may prove effective against endemic MERS-CoV in the Middle East, circulating human CoV, and, possibly most importantly, emerging CoV of the future.

Abstract: Unit 1. Basic Concepts in Nursing Unit 2. Biophysical & Psychosocial Concepts in Nursing Practice Unit 3. Concepts & Challenges in Patient Management Unit 4. Perioperative Concepts & Nursing Management Unit 5. Gas Exchange & Respiratory Function Unit 6. Cardiovascular, Circulatory and Hematologic Function Unit 7. Digestive & Gastrointestinal Function Unit 8. Metabolic and Endocrine Function Unit 9. Renal and Urinary Tract Function Unit 10. Reproductive Function Unit 11. Immunologic Function Unit 12. Integumentary Function Unit 13. Sensorineural Function Unit 14. Neurologic Function Unit 15. Musculoskeletal Function Unit 16. Other Acute Problem

Abstract: Background Prompt recognition of the reversal of respiratory failure may permit earlier discontinuation of mechanical ventilation, without harm to the patient. Methods We conducted a randomized, controlled trial in 300 adult patients receiving mechanical ventilation in medical and coronary intensive care units. In the intervention group, patients underwent daily screening of respiratory function by physicians, respiratory therapists, and nurses to identify those possibly capable of breathing spontaneously; successful tests were followed by two-hour trials of spontaneous breathing in those who met the criteria. Physicians were notified when their patients successfully completed the trials of spontaneous breathing. The control subjects had daily screening but no other interventions. In both groups, all clinical decisions, including the decision to discontinue mechanical ventilation, were made by the attending physicians. Results Although the 149 patients randomly assigned to the intervention group had more ...

Abstract: Gut Reactions is an interdisciplinary defense of the claim that emotions are perceptions of changes in the body. This thesis, pioneered by William James and resuscitated by Antonio Damasio, has been widely criticized for failing to acknowledge that emotions are meaningful insofar as they represent concerns, not respiratory function and blood pressure. Fear represents danger, sadness represents loss. To explain this fact, many researchers conclude that emotions must involve judgments regarding one's relationship to the environment. Prinz offers a new unified account of the emotions that reconciles these two theories. He argues that emotions are embodied appraisals-they are perceptions of the body, but, through the body, they also allow us to literally perceive danger, loss, and other matters of concern. The basic idea behind embodied appraisal theory is captured in the familiar notion of a "gut reaction," which has been overlooked by much emotion research. Using recent work in semantics, Prinz show how emotions can be meaningful without incorporating judgments or other cognitive states. Criticizing those who think that some emotions are social constructions, while others can be explained by evolutionary psychology, Prinz argues that all emotions are the same kind of phenomena, involving both nature and nurture. Prinz also distinguishes emotions from other affective states, such as motivations and moods, and offers a theory of emotional valence (what makes some emotions good and others bad). Ultimately, his theory of emotion consciousness is inspired by recent research on the neural correlates of conscious vision. Drawing a parallel between emotion consciousness and visual consciousness, Prinz shows that emotion is a form of perception in the fullest sense. Where vision reveals the identity of objects in a given situation, emotion reveals how that situation bears on our well-being.